TY  - BOOK
AU  - Howard, Barbara V
AU  - Umans, Jason G
TI  - Circulating Sphingolipids, Insulin, HOMA-IR and HOMA-B: the Strong Heart Family Study
SN  - 0012-1797
PY  - 2018///
KW  - *Cardiovascular Diseases/et [Etiology]
KW  - *Insulin Resistance
KW  - *Insulin/bl [Blood]
KW  - *Obesity/me [Metabolism]
KW  - *Overweight/me [Metabolism]
KW  - *Prediabetic State/et [Etiology]
KW  - *Sphingolipids/bl [Blood]
KW  - Adult
KW  - Arizona/ep [Epidemiology]
KW  - Biomarkers/bl [Blood]
KW  - Body Mass Index
KW  - Cardiovascular Diseases/eh [Ethnology]
KW  - Cardiovascular Diseases/ep [Epidemiology]
KW  - Ceramides/bl [Blood]
KW  - Ceramides/ch [Chemistry]
KW  - Cohort Studies
KW  - Cross-Sectional Studies
KW  - Fatty Acids/an [Analysis]
KW  - Fatty Acids/bl [Blood]
KW  - Female
KW  - Humans
KW  - Indians, North American
KW  - Insulin Resistance/eh [Ethnology]
KW  - Longitudinal Studies
KW  - Male
KW  - Middle Aged
KW  - Midwestern United States/ep [Epidemiology]
KW  - Obesity/bl [Blood]
KW  - Obesity/eh [Ethnology]
KW  - Obesity/pp [Physiopathology]
KW  - Overweight/bl [Blood]
KW  - Overweight/eh [Ethnology]
KW  - Overweight/pp [Physiopathology]
KW  - Prediabetic State/eh [Ethnology]
KW  - Prediabetic State/ep [Epidemiology]
KW  - Risk Factors
KW  - Sphingolipids/ch [Chemistry]
KW  - Young Adult
KW  - MedStar Health Research Institute
KW  - Journal Article
N1  - Available online from MWHC library: 1995 - present (after 3 months), Available in print through MWHC library: 1999 - 2006
N2  - Copyright (c) 2018 by the American Diabetes Association; Experimental studies suggest ceramides may play a role in insulin resistance. However, the relationships of circulating ceramides and related sphingolipids with plasma insulin have been underexplored in humans. We measured 15 ceramide and sphingomyelin species in fasting baseline samples from the Strong Heart Family Study, a prospective cohort of American Indians. We examined sphingolipid associations with both baseline and follow-up measures of plasma insulin, Homeostatic Model Assessment of Insulin Resistance (HOMAIR) and Homeostatic Model Assessment of beta-cell function (HOMAB) after adjustment for risk factors. Among 2086 participants without diabetes, higher levels of plasma ceramides carrying the fatty acids 16:0 (16 carbons, 0 double bond), 18:0, 20:0 or 22:0 were associated with higher plasma insulin and higher HOMAIR at baseline and at follow-up an average of 5.4 years later. For example, a two-fold higher baseline concentration of ceramide-16:0 was associated with 14% higher baseline insulin (p<0.0001). Associations between sphingomyelin species carrying 18:0, 20:0, 22:0 or 24:0 and insulin were modified by BMI (p<0.003): higher levels were associated with lower fasting insulin, HOMAIR and HOMAB among those with normal BMI. Our study suggests lowering circulating ceramides might be a target in pre-diabetes, and targeting circulating sphingomyelins should take into account BMI
UR  - https://dx.doi.org/10.2337/db17-1449
ER  -