A Comparative Study of the ReCell Device and Autologous Spit-thickness Meshed Skin Graft in the Treatment of Acute Burn Injuries. 

 -  2018 
<br/><br/>Available online through MWHC library: 2006 - present, Available in print through MWHC library: 2006 - present 
<br/><br/> Conclusions: This study provides evidence that the treatment of DPT burns with ASCS results in comparable healing, with significantly reduced donor site size and pain and improved appearance relative to STSG.  Introduction: Early excision and autografting are standard care for deeper burns. However, donor sites are a source of significant morbidity. To address this, the ReCell Autologous Cell Harvesting Device (ReCell) was designed for use at the point-of-care to prepare a non-cultured, autologous skin cell suspension (ASCS) capable of epidermal regeneration utilizing minimal donor skin.  Methods: A prospective study was conducted to evaluate the clinical performance of ReCell versus meshed split-thickness skin grafts (STSG, Control) for the treatment of deep partial-thickness (DPT) burns. Effectiveness measures were assessed to 1 year for both ASCS and Control treatment sites and donor sites, including the incidence of healing, scarring, and pain.  Results: At 4 weeks, 98% of the ASCS-treated sites were healed compared to 100% of the Controls. Pain and assessments of scarring at the treatment sites were reported to be similar between groups. Significant differences were observed between ReCell and Control donor sites. The mean ReCell donor area was approximately 40 times smaller than that of the Control (194.1+/-158.5 cm2; p<0.0001), and after 1 week, significantly more ReCell donor sites were healed than Controls (p=0.04). Over the first 16 weeks, patients reported significantly less pain at the ReCell donor sites compared with Controls (p<=0.05 at each time point). Long-term, patients reported higher satisfaction with ReCell donor site outcomes compared with the Controls. 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>1559-047X 
<br/><br/><label>Standard No.: </label>10.1093/jbcr/iry029 [doi] 5002035 [pii] 
<br/><br/><label>Subjects--Topical Terms: </label><br/>*Burns/su [Surgery]<br/>*Skin Transplantation<br/>*Tissue and Organ Harvesting/is [Instrumentation]<br/>Adolescent<br/>Adult<br/>Female<br/>Humans<br/>Male<br/>Middle Aged<br/>Prospective Studies<br/>Surgical Mesh<br/>Transplantation, Autologous<br/>Treatment Outcome<br/>Wound Healing<br/>Young Adult
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Washington Hospital Center
<br/><br/><label>Index Terms--Occupation: </label><br/>Surgery/Burn Services
<br/><br/><label>Index Terms--Function: </label><br/>Journal Article