TY  - BOOK
AU  - Chang, Jason J
TI  - Sulfonylurea drug pretreatment and functional outcome in diabetic patients with acute intracerebral hemorrhage
SN  - 0022-510X
PY  - 2017///
KW  - *Cerebral Hemorrhage/co [Complications]
KW  - *Cerebral Hemorrhage/dt [Drug Therapy]
KW  - *Diabetes Complications/dt [Drug Therapy]
KW  - *Sulfonylurea Compounds/ad [Administration & Dosage]
KW  - Acute Disease
KW  - Cerebral Hemorrhage/pa [Pathology]
KW  - Diabetes Complications/pa [Pathology]
KW  - Female
KW  - Humans
KW  - Linear Models
KW  - Logistic Models
KW  - Male
KW  - Middle Aged
KW  - Multivariate Analysis
KW  - Pilot Projects
KW  - Prospective Studies
KW  - Retrospective Studies
KW  - Severity of Illness Index
KW  - Treatment Outcome
KW  - MedStar Washington Hospital Center
KW  - Critical Care Medicine
KW  - Journal Article
N2  - CONCLUSION: SFU pretreatment may be an independent predictor for improved functional outcome in diabetic patients with acute ICH. This association requires independent confirmation in a large prospective cohort study. Copyright (c) 2017 Elsevier B.V. All rights reserved; METHODS: We retrospectively analyzed a cohort of diabetic patients presenting with acute ICH at a tertiary care center. Study inclusion criteria included spontaneous ICH etiology and age>18years. Baseline clinical severity was documented using ICH-score. Hematoma volumes (HV) on admission were calculated using ABC/2 formula. Unfavorable functional outcome was documented as discharge modified Rankin Scale scores 2-6; PURPOSE: Intracerebral hemorrhage (ICH) is associated with poor clinical outcome and high mortality. Sulfonylurea (SFU) use may be a viable therapy for inhibiting sulfonylurea receptor-1 and NC<sub>Ca-ATP</sub> channels and reducing perihematomal edema and blood-brain barrier disruption. We sought to evaluate the effects of prehospital SFU use with outcomes in diabetic patients with acute ICH; RESULTS: 230 diabetic patients with acute ICH fulfilled inclusion criteria (mean age 64+/-13years, men 53%). SFU pretreatment was documented in 16% of the study population. Patients with SFU pretreatment had significantly (p<0.05) lower median ICH-scores (0, IQR: 0-2) and median admission HV (4cm<sup>3</sup>, IQR: 1-12) compared to controls [ICH-score: 1 (IQR: 0-3); HV: 9cm<sup>3</sup> (IQR: 3-20)]. SFU pretreatment was independently (p=0.033) and negatively associated with the cubed root of admission HV (linear regression coefficient: -0.208; 95%CI: -0.398 to -0.017) in multiple linear regression analyses adjusting for potential confounders. Pretreatment with SFU was also independently (p=0.033) associated with lower likelihood of unfavorable functional outcome (OR=0.19; 95%CI: 0.04-0.88) in multivariable logistic regression models adjusting for potential confounders
UR  - https://dx.doi.org/10.1016/j.jns.2017.08.3252
ER  -