TY  - BOOK
AU  - Gomez-Lobo, Veronica
AU  - Patel, Vrunda
TI  - Non-Cytotoxic Related Primary Ovarian Insufficiency in Adolescents: Multicenter Case Series and Review
SN  - 1083-3188
PY  - 2018///
KW  - *Primary Ovarian Insufficiency/et [Etiology]
KW  - Adolescent
KW  - Amenorrhea/et [Etiology]
KW  - Female
KW  - Gonadal Dysgenesis/co [Complications]
KW  - Humans
KW  - Puberty, Delayed/et [Etiology]
KW  - Young Adult
KW  - MedStar Washington Hospital Center
KW  - Obstetrics and Gynecology/Pediatric and Adolescent
KW  - Journal Article
N1  - Available online through MWHC library: 2002 - present
N2  - CONCLUSIONS: Non-cytotoxic POI in adolescents is an uncommon condition with only 64 cases in 6 institutions over 7 years. These patients may not undergo complete etiological workup. Aside from 45X, the most common etiologies are X-chromosome abnormalities or galactosemia; Copyright (c) 2018 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved; DESIGN: Case series of patients with POI; INTERVENTIONS: Review and data extraction of records identified with ICD-9 and ICD-10 codes; MAIN OUTCOME MEASURE(S): Data were analyzed for signs and symptoms, workup, and treatments. Complete work-up was based on ACOG guidelines. Characteristics of patients with POI presenting with delayed puberty/primary amenorrhea vs secondary amenorrhea were compared; RESULTS: 135 records were identified. Those who had received cytotoxic therapy (n=52), 46XY gonadal dysgenesis (n=7),or on review did not have POI (n=19) were excluded. Of 57 remaining cases, 16 were 45X, 2 had galactosemia and 4 had X-chromosome abnormalities. Most did not undergo full etiologic evaluation. Girls diagnosed following primary amenorrhea/delayed puberty were less symptomatic and more likely to receive an estrogen patch than those diagnosed following secondary amenorrhea; SETTING: Six tertiary care institutions ParticipantsPatients presenting from 2007-2014 aged 13-21 years diagnosed with non-cytotoxic POI, exclusions gonadotoxic therapy, 46XY gonadal dysgenesis, lack of evidence of hypergonadotropic hypogonadism on chart review; STUDY OBJECTIVE: Primary ovarian insufficiency (POI) in adolescents not due to cytotoxic therapy has not been well studied. Causes of POI have been described in adults, but adolescents may represent a unique subset necessitating a targeted approach to diagnosis, work-up and treatment. We sought to better characterize adolescent POI through a descriptive multicenter study
UR  - https://dx.doi.org/10.1016/j.jpag.2018.06.006
ER  -