TY  - BOOK
AU  - Virk, Mrigender S
TI  - Severe Underestimation of Serum Na following IVIG Treatment
SN  - 0007-5027
PY  - 2018///
KW  - *Immunoglobulins, Intravenous/tu [Therapeutic Use]
KW  - *Purpura, Thrombocytopenic, Idiopathic/bl [Blood]
KW  - *Purpura, Thrombocytopenic, Idiopathic/dt [Drug Therapy]
KW  - *Sodium/bl [Blood]
KW  - Adolescent
KW  - Diagnostic Errors
KW  - Female
KW  - Humans
KW  - Purpura, Thrombocytopenic, Idiopathic/di [Diagnosis]
KW  - Purpura, Thrombocytopenic, Idiopathic/pp [Physiopathology]
KW  - Reproducibility of Results
KW  - MedStar Washington Hospital Center
KW  - Pathology
KW  - Journal Article
N2  - Current chemistry analyzers measure ion concentration using ion- selective electrodes; however, may differ in the specific technology at the bedside versus the central laboratory. Instruments utilized for point-of-care testing (POCT) at the bedside use direct ion-selective electrodes, whereas central-laboratory analyzers use indirect ion-selective electrodes. Under most circumstances, these instruments will deliver the same result; however, various substances can cause interferences in one or the other. An 18-year-old Hispanic woman with a history of immune thrombocytopenic purpura (ITP) presented at Children's National Medical Center (CNMC) with a severe headache and required intravenous immunoglobulin (IVIG) therapy. Because a discrepancy developed between her point-of-care and central-laboratory sodium values, another instrument was used to retest the central-laboratory plasma specimens. The results were more in agreement with those from the point-of-care instrument and revealed a unique interference in sodium measurement related to IVIG use
UR  - https://dx.doi.org/10.1093/labmed/lmy025
ER  -