TY  - BOOK
AU  - Ben-Dor, Itsik
AU  - Bond, Elizabeth
AU  - Buchanan, Kyle
AU  - Kiramijyan, Starkis
AU  - Koifman, Edward
AU  - Okubagzi, Petros
AU  - Pichard, Augusto D
AU  - Rogers, Toby
AU  - Satler, Lowell F
AU  - Shults, Christian
AU  - Steinvil, Arie
AU  - Torguson, Rebecca
AU  - Waksman, Ron
AU  - Xu, Linzhi
TI  - Utility of an additive frailty tests index score for mortality risk assessment following transcatheter aortic valve replacement
SN  - 0002-8703
PY  - 2018///
KW  - *Frailty/di [Diagnosis]
KW  - *Geriatric Assessment/mt [Methods]
KW  - *Risk Assessment/mt [Methods]
KW  - *Transcatheter Aortic Valve Replacement/mo [Mortality]
KW  - Aged
KW  - Aged, 80 and over
KW  - Aortic Valve Stenosis/su [Surgery]
KW  - Body Mass Index
KW  - Female
KW  - Hand Strength
KW  - Humans
KW  - Male
KW  - Mortality
KW  - Preoperative Care/mt [Methods]
KW  - Research Design
KW  - Retrospective Studies
KW  - Risk Factors
KW  - Transcatheter Aortic Valve Replacement/mt [Methods]
KW  - United States/ep [Epidemiology]
KW  - Walk Test/mt [Methods]
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
N2  - BACKGROUND: The impact of frailty assessment on outcomes in patients undergoing transcatheter aortic valve replacement (TAVR) remains unclear. Our aim was to evaluate the individual effect of each frailty test and the utility of an additive frailty index score on short- and long-term survival following TAVR; CONCLUSIONS: Frailty status and a higher frailty index score were associated with increased 1-year mortality risk following TAVR; Copyright (c) 2018 Elsevier Inc. All rights reserved; METHODS: Retrospective analysis of consecutive TAVR patients for whom a complete set of frailty tests was obtained: algorithm defined grip strength and 5-m walking tests, body mass index <20 kg/m<sup>2</sup>, Katz activities of daily living <=4/6, serum albumin <3.5 g/dL. Frailty status was defined as having 3 or more positive frailty tests. Included were 498 patients with a mean age of 82+/-8 years; RESULTS: Frailty status, observed in 266 (53%) patients, was associated with both 30-day and 1-year mortality (6% vs. 2%, P=.016; 20% vs. 9%, P<.001; within the respective frailty groups). As compared to 0-2 frailty criteria, a higher frailty index score was associated with increased risk of death at 1 year (OR 2.23; 95% CI 1.14-4.34; P=.019 and OR 3.30; 95% CI 1.36-8.00; P=.008 for 3 and 4-5 frailty criteria met, respectively). In Cox regression analysis, frailty status was correlated with 1-year mortality (HR=2.2; 95%CI 1.25-3.96; P=.007), and a higher frailty index was associated with increased mortality risk (HR=2.0; 95% CI 1.08-3.7; P=.027; and HR=3.07; 95% CI 1.4-6.7; P=.005; for any 3, and 4-5 frailty criteria, respectively)
UR  - https://dx.doi.org/10.1016/j.ahj.2018.01.007
ER  -