TY  - BOOK
AU  - Doroslovacki, Pavle
TI  - Factors Associated with Occurrence of Radiation-induced Optic Neuropathy at "Safe" Radiation Dosage
SN  - 0882-0538
PY  - 2017///
KW  - *Optic Neuritis/ep [Epidemiology]
KW  - *Radiation Injuries/ep [Epidemiology]
KW  - *Radiosurgery/ae [Adverse Effects]
KW  - Adolescent
KW  - Adult
KW  - Aged
KW  - Dose-Response Relationship, Radiation
KW  - Female
KW  - Follow-Up Studies
KW  - Humans
KW  - Incidence
KW  - Male
KW  - Middle Aged
KW  - Nerve Fibers/pa [Pathology]
KW  - Nerve Fibers/re [Radiation Effects]
KW  - Optic Nerve/dg [Diagnostic Imaging]
KW  - Optic Nerve/re [Radiation Effects]
KW  - Optic Neuritis/di [Diagnosis]
KW  - Optic Neuritis/et [Etiology]
KW  - Pituitary Neoplasms/rt [Radiotherapy]
KW  - Radiation Dosage
KW  - Radiation Injuries/di [Diagnosis]
KW  - Radiation Injuries/et [Etiology]
KW  - Retrospective Studies
KW  - Risk Factors
KW  - United States/ep [Epidemiology]
KW  - Young Adult
KW  - MedStar Washington Hospital Center
KW  - Ophthalmology
KW  - Journal Article
N2  - BACKGROUND: Radiation-induced optic neuropathy (RION) is a rare, and often visually devastating, complication of radiation therapy (RT) near the anterior visual pathways; CONCLUSION: RION can occur at doses below published "safe" thresholds and with different RT modalities. Smoking and hypertension might be risk factors for RION; METHODS: A retrospective case series of patients who developed RION at a tertiary medical center, followed by a case-control study comparing RION cases with matched controls who received RT; RESULTS: Thirteen patients (18 eyes) with RION were identified. Radiation modalities included external beam photon radiation, whole brain radiation, stereotactic radiosurgery, proton beam, and unknown. Most patients received doses below published "safe" thresholds (<55 Gy; <8-10 Gy for stereotactic radiosurgery). There was no statistically significant difference in prevalence of vasculopathic factors between cases and controls; on subgroup analysis in three patients who received surprisingly low radiation doses, smoking (p=0.05) and hypertension (p=0.02) appeared more prevalent
UR  - https://dx.doi.org/10.1080/08820538.2017.1346133
ER  -