TY  - BOOK
AU  - Garcia-Garcia, Hector M
AU  - Hideo-Kajita, Alexandre
AU  - Ho, Gavin
AU  - Kuku, Kayode
AU  - Soud, Mohamad
AU  - Waksman, Ron
TI  - Impact of statins preloading before PCI on periprocedural myocardial infarction among stable angina pectoris patients undergoing percutaneous coronary intervention: A meta-analysis of randomized controlled trials. [Review]
SN  - 1878-0938
PY  - 2018///
KW  - *Angina, Stable/dt [Drug Therapy]
KW  - *Hydroxymethylglutaryl-CoA Reductase Inhibitors/tu [Therapeutic Use]
KW  - *Myocardial Infarction/th [Therapy]
KW  - *Percutaneous Coronary Intervention
KW  - *Postoperative Complications/pc [Prevention & Control]
KW  - *Preoperative Care/mt [Methods]
KW  - *Randomized Controlled Trials as Topic
KW  - Angina, Stable/et [Etiology]
KW  - Global Health
KW  - Humans
KW  - Morbidity
KW  - Myocardial Infarction/co [Complications]
KW  - Postoperative Complications/ep [Epidemiology]
KW  - Survival Rate
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
KW  - Review
N1  - Available in print through MWHC library: 2002 - present
N2  - Copyright (c) 2018 Elsevier Inc. All rights reserved; It has been shown that statins preloading, before percutaneous coronary intervention (PCI), may reduce the risk of cardiovascular outcomes for acute coronary syndrome patients. Nevertheless, the effect of such pretreatment among patients with stable angina pectoris (SAP) is still debatable. We performed a systematic review and updated meta-analysis of the literature to evaluate the efficacy of short-term statins preloading on periprocedural myocardial infarction (PMI) incidence and mortality after PCI. We included 13 randomized control trials that examined statins preloading in adult patients with SAP undergoing PCI. While the use of preloading statins significantly reduced PMI, the benefit of statins pretreatment on long-term mortality was not statistically significant; SHORT SUMMARY: High dose statins preloading prior to elective PCI was associated with a significant reduction in PMI in SAP patients. The mortality benefit of such intervention will need to be addressed by further large randomized studies. The routine use of statins in stable patients before PCI should be considered if no contraindications are present
UR  - https://dx.doi.org/10.1016/j.carrev.2018.07.016
ER  -