TY - BOOK AU - Cho, Won K TI - End-stage renal disease is associated with increased post endoscopic retrograde cholangiopancreatography adverse events in hospitalized patients SN - 1007-9327 PY - 2018/// KW - *Cholangiopancreatography, Endoscopic Retrograde/ae [Adverse Effects] KW - *Kidney Failure, Chronic/co [Complications] KW - *Pancreatitis/ep [Epidemiology] KW - *Postoperative Hemorrhage/ep [Epidemiology] KW - Aged KW - Female KW - Hospital Mortality KW - Humans KW - Length of Stay/ec [Economics] KW - Length of Stay/sn [Statistics & Numerical Data] KW - Male KW - Middle Aged KW - Pancreatitis/et [Etiology] KW - Postoperative Hemorrhage/et [Etiology] KW - Retrospective Studies KW - Risk Factors KW - MedStar Washington Hospital Center KW - Medicine/Gastroenterology KW - Journal Article N2 - AIM: To determine if end-stage renal disease (ESRD) is a risk factor for post endoscopic retrograde cholangiopancreatography (ERCP) adverse events (AEs); CONCLUSION: ESRD is a risk factor for post-ERCP AEs and is associated with higher hospital mortality. Careful selection and close monitoring is warranted to improve outcomes; METHODS: We performed a retrospective cohort study using the Nationwide Inpatient Sample (NIS) 2011-2013. We identified adult patients who underwent ERCP using the International Classification of Diseases 9^th Revision (ICD-9-CM). Included patients were divided into three groups: ESRD, chronic kidney disease (CKD), and control. The primary outcome was post-ERCP AEs including pancreatitis, bleeding, and perforation determined based on specific ICD-9-CM codes. Secondary outcomes were length of hospital stay, in-hospital mortality, and admission cost. AEs and mortality were compared using multivariate logistic regression analysis; RESULTS: There were 492175 discharges that underwent ERCP during the 3 years. The ESRD and CKD groups contained 7347 and 39403 hospitalizations respectively, whereas the control group had 445424 hospitalizations. Post-ERCP pancreatitis (PEP) was significantly higher in the ESRD group (8.3%) compared to the control group (4.6%) with adjusted odd ratio (aOR) = 1.7 (95%CI: 1.4-2.1, ^a P < 0.001). ESRD was associated with significantly higher ERCP-related bleeding (5.1%) compared to the control group 1.5% (aOR = 1.86, 95%CI: 1.4-2.4, ^a P < 0.001). ESRD had increased hospital mortality 7.1% vs 1.15% in the control OR = 6.6 (95%CI: 5.3-8.2, ^a P < 0.001), longer hospital stay with adjusted mean difference (aMD) = 5.9 d (95%CI: 5.0-6.7 d, ^a P < 0.001) and higher hospitalization charges aMD = UR - https://dx.doi.org/10.3748/wjg.v24.i41.4691 ER -