TY  - BOOK
AU  - Attaran, Saina
AU  - Ben-Dor, Itsik
AU  - Buchanan, Kyle
AU  - Gajanana, Deepakraj
AU  - Iantorno, Micaela
AU  - Kolm, Paul
AU  - Okubagzi, Petros
AU  - Rogers, Toby
AU  - Satler, Lowell F
AU  - Thourani, Vinod H
AU  - Torguson, Rebecca
AU  - Waksman, Ron
AU  - Weintraub, William S
AU  - Zhang, Cheng
TI  - Transcatheter Aortic Valve Replacement in Patients With Symptomatic Severe Aortic Stenosis and Prior External Chest Radiation
SN  - 1878-0938
PY  - 2019///
KW  - *Aortic Valve Stenosis/su [Surgery]
KW  - *Aortic Valve/su [Surgery]
KW  - *Cancer Survivors
KW  - *Thorax/re [Radiation Effects]
KW  - *Transcatheter Aortic Valve Replacement
KW  - Aged
KW  - Aged, 80 and over
KW  - Aortic Valve Stenosis/dg [Diagnostic Imaging]
KW  - Aortic Valve Stenosis/mo [Mortality]
KW  - Aortic Valve Stenosis/pp [Physiopathology]
KW  - Aortic Valve/dg [Diagnostic Imaging]
KW  - Aortic Valve/pp [Physiopathology]
KW  - District of Columbia/ep [Epidemiology]
KW  - Female
KW  - Heart Block/ep [Epidemiology]
KW  - Heart Block/th [Therapy]
KW  - Hemodynamics
KW  - Humans
KW  - Length of Stay
KW  - Male
KW  - Middle Aged
KW  - Prevalence
KW  - Prospective Studies
KW  - Radiotherapy
KW  - Risk Factors
KW  - Severity of Illness Index
KW  - Time Factors
KW  - Transcatheter Aortic Valve Replacement/ae [Adverse Effects]
KW  - Transcatheter Aortic Valve Replacement/mo [Mortality]
KW  - Treatment Outcome
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
N1  - Available in print through MWHC library: 2002 - present
N2  - BACKGROUND/PURPOSE: Surgical aortic valve replacement (SAVR) in patients with symptomatic severe aortic stenosis (AS) and prior chest radiation is associated with poor outcomes in comparison with patients without prior radiation. Our objective was to compare clinical outcomes of patients with and without prior chest radiation undergoing transcatheter aortic valve replacement (TAVR) for symptomatic severe AS; CONCLUSIONS: Thus, TAVR appears to be a safe treatment option in the short and medium term for patients with symptomatic severe AS and prior chest radiation; Copyright (c) 2019. Published by Elsevier Inc; METHODS/MATERIALS: Between January 2003 and January 2017, 1150 patients underwent TAVR at our institution. Of these, 44 had prior chest radiation. Baseline demographic and clinical characteristics, procedural details, and clinical outcomes were prospectively collected; RESULTS: Patients with prior chest radiation were younger, 76+/-13years, compared with those without prior chest radiation, 82+/-8years (p=0.002). Median Society of Thoracic Surgeons score for chest radiation patients was 7+/-4, compared to 8+/-5 in those without prior radiation. Despite higher prevalence of complete heart block, there was no significant difference between the 2 groups with regard to the need for permanent pacemaker implantation. There was a trend toward longer length of intensive care unit stay in chest radiation patients, but there was no significant difference in 30-day or 1-year mortality
UR  - https://dx.doi.org/10.1016/j.carrev.2019.02.015
ER  -