Copyright (c) 2019, StatPearls Publishing LLC. Fibromyalgia (FM) is a condition characterized by chronic widespread musculoskeletal pain. Fatigue, cognitive disturbance, psychiatric and multiple somatic symptoms often accompany the disorder. Fibromyalgia has an unknown etiology and uncertain pathophysiology.[1][2] There is no evidence of tissue inflammation despite symptoms of soft tissue pain. Fibromyalgia is a pain regulation disorder as suggested by ongoing research and often classifies as a form of central sensitization syndrome.[3]