TY  - BOOK
AU  - Barac, Ana
TI  - Chimeric Antigen Receptor T-Cell Therapy for Cancer and Heart: JACC Council Perspectives. [Review]
SN  - 0735-1097
PY  - 2019///
KW  - *Cardiovascular Diseases/et [Etiology]
KW  - *Cytokine Release Syndrome/et [Etiology]
KW  - *Immunotherapy, Adoptive/ae [Adverse Effects]
KW  - *Neoplasms/th [Therapy]
KW  - *Receptors, Chimeric Antigen
KW  - Clinical Trials as Topic
KW  - Female
KW  - Humans
KW  - Middle Aged
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
KW  - Review
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007
N2  - Chimeric antigen receptor (CAR) T-cell therapy has significantly advanced the treatment of patients with relapsed and refractory hematologic malignancies and is increasingly investigated as a therapeutic option of other malignancies. The main adverse effect of CAR T-cell therapy is potentially life-threatening cytokine release syndrome (CRS). Clinical cardiovascular (CV) manifestations of CRS include tachycardia, hypotension, troponin elevation, reduced left ventricular ejection fraction, pulmonary edema, and cardiogenic shock. Although insults related to CRS toxicity might be transient and reversible in most instances in patients with adequate CV reserve, they can be particularly challenging in higher-risk, often elderly patients with pre-existing CV disease. As the use of CAR T-cell therapy expands to include a wider patient population, careful patient selection, pre-treatment cardiac evaluation, and CV risk stratification should be considered within the CAR T-cell treatment protocol. Early diagnosis and management of CV complications in patients with CRS require awareness and multidisciplinary collaboration. Copyright (c) 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved
UR  - https://dx.doi.org/10.1016/j.jacc.2019.10.049
ER  -