Bronchial Rheoplasty For Treatment of Chronic Bronchitis: 12 Month Results from a Multi-Center Study. 

 -  2020 
<br/><br/>Available online from MWHC library: July 1997 - present, Available in print through MWHC library: 1999 - present 
<br/><br/> CONCLUSIONS: This study provides the first clinical evidence of the feasibility, safety and initial outcomes of Bronchial Rheoplasty in symptomatic chronic bronchitis patients.  MEASUREMENTS AND MAIN RESULTS: Bronchial Rheoplasty was performed in all 30 patients [63% male, mean age 67 (standard deviation 7.4), post-bronchodilator Forced Expiratory Volume in 1 second 65% (21%), COPD Assessment Test score 25.6 (7.1), and St. George's Respiratory Questionnaire score 59.6 (15.3)]. There were no device-related and 4 procedure-related serious adverse events through 6 months, and none thereafter through 12 months. The most frequent non-serious, device and/or procedure related event through 6 months was mild hemoptysis in 47% (14/30) patients. Histologically, mean goblet cell hyperplasia score was statistically significantly reduced (p<0.001). Significant changes from baseline to 6 months in COPD Assessment Test (mean -7.9; median -8.0; p=0.0002) and St. George's Respiratory Questionnaire (mean -14.6; median -7.2; p=0.0002) were observed, with similar observations through 12 months.  METHODS: Pooled analysis of two separate studies enrolling 30 patients undergoing bilateral Bronchial Rheoplasty. Follow-up through 6 months (primary outcome) and 12 months included assessment of adverse events, airway histology and changes in symptoms using the COPD Assessment Test and St. George's Respiratory Questionnaire.  OBJECTIVES: To evaluate the feasibility, safety and initial outcomes of Bronchial Rheoplasty in chronic bronchitis patients.  RATIONALE: Chronic bronchitis is characterized by productive cough with excessive mucus production, resulting in quality of life impairment and increased exacerbation risk. Bronchial Rheoplasty uses an endobronchial catheter to apply non-thermal pulsed electric fields to the airways. Preclinical studies demonstrated epithelial ablation followed by regeneration of normalized epithelium. 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>1073-449X 
<br/><br/><label>Standard No.: </label>10.1164/rccm.201908-1546OC [doi] 
<br/><br/><label>Subjects--Topical Terms: </label><br/>*Ablation Techniques/mt [Methods]<br/>*Bronchi/su [Surgery]<br/>*Bronchitis, Chronic/su [Surgery]<br/>Aged<br/>Bronchitis, Chronic/pp [Physiopathology]<br/>Disease Progression<br/>Female<br/>Follow-Up Studies<br/>Forced Expiratory Volume<br/>Humans<br/>Male<br/>Prospective Studies<br/>Quality of Life<br/>Time Factors<br/>Treatment Outcome
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Franklin Square Medical Center
<br/><br/><label>Index Terms--Occupation: </label><br/>Angelos Center for Lung Disease
<br/><br/><label>Index Terms--Function: </label><br/>Journal Article