04256nam a22006017a 4500
200709s20202020 xxu||||| |||| 00| 0 eng d
1073-449X
10.1164/rccm.201908-1546OC [doi]
Ovid MEDLINE(R)
32407638
Bronchial Rheoplasty For Treatment of Chronic Bronchitis: 12 Month Results from a Multi-Center Study.
American Journal of Respiratory & Critical Care Medicine. 202(5):681-689, 2020 09 01.
Am J Respir Crit Care Med. 202(5):681-689, 2020 09 01.
Am J Respir Crit Care Med. 2020 May 14
American journal of respiratory and critical care medicine
2020
FY2021
aheadofprint
ppublish
2020-07-09
American Journal of Respiratory & Critical Care Medicine. 2020 May 14
FY2020
Available online from MWHC library: July 1997 - present, Available in print through MWHC library: 1999 - present
CONCLUSIONS: This study provides the first clinical evidence of the feasibility, safety and initial outcomes of Bronchial Rheoplasty in symptomatic chronic bronchitis patients.
MEASUREMENTS AND MAIN RESULTS: Bronchial Rheoplasty was performed in all 30 patients [63% male, mean age 67 (standard deviation 7.4), post-bronchodilator Forced Expiratory Volume in 1 second 65% (21%), COPD Assessment Test score 25.6 (7.1), and St. George's Respiratory Questionnaire score 59.6 (15.3)]. There were no device-related and 4 procedure-related serious adverse events through 6 months, and none thereafter through 12 months. The most frequent non-serious, device and/or procedure related event through 6 months was mild hemoptysis in 47% (14/30) patients. Histologically, mean goblet cell hyperplasia score was statistically significantly reduced (p<0.001). Significant changes from baseline to 6 months in COPD Assessment Test (mean -7.9; median -8.0; p=0.0002) and St. George's Respiratory Questionnaire (mean -14.6; median -7.2; p=0.0002) were observed, with similar observations through 12 months.
METHODS: Pooled analysis of two separate studies enrolling 30 patients undergoing bilateral Bronchial Rheoplasty. Follow-up through 6 months (primary outcome) and 12 months included assessment of adverse events, airway histology and changes in symptoms using the COPD Assessment Test and St. George's Respiratory Questionnaire.
OBJECTIVES: To evaluate the feasibility, safety and initial outcomes of Bronchial Rheoplasty in chronic bronchitis patients.
RATIONALE: Chronic bronchitis is characterized by productive cough with excessive mucus production, resulting in quality of life impairment and increased exacerbation risk. Bronchial Rheoplasty uses an endobronchial catheter to apply non-thermal pulsed electric fields to the airways. Preclinical studies demonstrated epithelial ablation followed by regeneration of normalized epithelium.
English
*Ablation Techniques/mt [Methods]
*Bronchi/su [Surgery]
*Bronchitis, Chronic/su [Surgery]
Aged
Bronchitis, Chronic/pp [Physiopathology]
Disease Progression
Female
Follow-Up Studies
Forced Expiratory Volume
Humans
Male
Prospective Studies
Quality of Life
Time Factors
Treatment Outcome
MedStar Franklin Square Medical Center
Angelos Center for Lung Disease
Journal Article
Krimsky, William S
Dabscheck EJ, Fernandez-Bussy S, Ing AJ, Irving LB, Krimsky WS, Saghaie T, Snell GI, Steinfort DP, Valipour A, Waldstreicher J, Williamson JP
https://dx.doi.org/10.1164/rccm.201908-1546OC
https://dx.doi.org/10.1164/rccm.201908-1546OC
https://dx.doi.org/10.1164/rccm.201908-1546OC
https://dx.doi.org/10.1164/rccm.201908-1546OC
https://dx.doi.org/10.1164/rccm.201908-1546OC
https://dx.doi.org/10.1164/rccm.201908-1546OC
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Article
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authcat
2020-07-09
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32407638
32407638
2020-07-09
2020-07-09
ART
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5049