TY - BOOK AU - Dan, Kazuhiro AU - Garcia-Garcia, Hector M AU - Hideo-Kajita, Alexandre AU - Ozaki, Yuichi AU - Shlofmitz, Evan AU - Waksman, Ron TI - Novel Indices of Coronary Physiology: Do We Need Alternatives to Fractional Flow Reserve?. [Review] SN - 1941-7640 PY - 2020/// KW - *Cardiac Catheterization KW - *Cardiac Imaging Techniques KW - *Coronary Artery Disease/di [Diagnosis] KW - *Coronary Vessels/dg [Diagnostic Imaging] KW - *Fractional Flow Reserve, Myocardial KW - Cardiac Catheterization/is [Instrumentation] KW - Cardiac Catheters KW - Coronary Artery Disease/pp [Physiopathology] KW - Coronary Vessels/pp [Physiopathology] KW - Humans KW - Predictive Value of Tests KW - Prognosis KW - Reproducibility of Results KW - Transducers, Pressure KW - MedStar Heart & Vascular Institute KW - MedStar Washington Hospital Center KW - Journal Article N1 - Available online from MWHC library: 2008 - present N2 - Fractional flow reserve is the current invasive gold standard for assessing the ischemic potential of an angiographically intermediate coronary stenosis. Procedural cost and time, the need for coronary vessel instrumentation, and the need to administer adenosine to achieve maximal hyperemia remain integral components of invasive fractional flow reserve. The number of new alternatives to fractional flow reserve has proliferated over the last ten years using techniques ranging from alternative pressure wire metrics to anatomic simulation via angiography or intravascular imaging. This review article provides a critical description of the currently available or under-development alternatives to fractional flow reserve with a special focus on the available evidence, pros, and cons for each with a view towards their clinical application in the near future for the functional assessment of coronary artery disease UR - https://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.008487 UR - https://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.008487 ER -