Bone metastasis from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); a case report. 

 -  2021 
<br/><br/>Available online from MWHC library: 2001 - present 
<br/><br/> BACKGROUND: The term non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed as a non-malignant thyroid lesion with indolent behavior that does not require post-operative radio-iodine treatment. We are reporting a case of NIFTP with bone metastasis that is the second case reported so far.  CASE PRESENTATION: We describe a 38-year-old woman who presented with an indeterminate thyroid nodule and underwent total thyroidectomy with the finding of NIFTP on careful pathologic examination. However, her initial follow-up evaluation revealed a serum thyroglobulin level of > 300 ng/ml and a diagnostic whole body 131I scan demonstrated a focus of increased uptake in the left hemipelvis, confirmed on CT scan to be a lytic lesion in the left iliac bone. She was treated with 7.4GBq (200 mCi) of 131I and her follow-up 1 year later revealed an undetectable serum thyroglobulin and a negative whole body 131I scan with no visible uptake in the iliac bone indicating an excellent response.  CONCLUSION: This case presentation reminds us to be alert to the rare occurrence of distant metastasis in NIFTP and the need for a case by case analysis and continuing post-operative follow-up for detection of residual or recurrent disease. Copyright © 2021. The Author(s). 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>1472-6823 
<br/><br/><label>Standard No.: </label>10.1186/s12902-021-00883-7 [doi] 10.1186/s12902-021-00883-7 [pii] PMC8567706 [pmc] 
<br/><br/><label>Subjects--Topical Terms: </label><br/>*Adenocarcinoma, Follicular/sc [Secondary]<br/>*Bone Neoplasms/sc [Secondary]<br/>*Thyroid Neoplasms/pa [Pathology]<br/>*Thyroid Nodule/pa [Pathology]<br/>Adenocarcinoma, Follicular/dg [Diagnostic Imaging]<br/>Adenocarcinoma, Follicular/rt [Radiotherapy]<br/>Adult<br/>Bone Neoplasms/dg [Diagnostic Imaging]<br/>Bone Neoplasms/rt [Radiotherapy]<br/>Cell Nucleus/pa [Pathology]<br/>Female<br/>Humans<br/>Ilium/dg [Diagnostic Imaging]<br/>Iodine Radioisotopes/tu [Therapeutic Use]<br/>Single Photon Emission Computed Tomography Computed Tomography<br/>Thyroid Cancer, Papillary/pa [Pathology]<br/>Thyroid Neoplasms/su [Surgery]<br/>Thyroid Nodule/su [Surgery]<br/>Thyroidectomy<br/>Tomography, X-Ray Computed
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Health Research Institute
<br/><br/><label>Index Terms--Function: </label><br/>Case Reports<br/>Journal Article