TY - BOOK AU - Darehzereshki, Ali TI - Apical Resection and Cryoinjury of Neonatal Mouse Heart SN - 1064-3745 PY - 2021/// KW - *Cardiac Surgical Procedures/ae [Adverse Effects] KW - *Cryosurgery/ae [Adverse Effects] KW - *Heart Injuries/pa [Pathology] KW - *Heart/ph [Physiology] KW - *Regeneration KW - *Ventricular Remodeling KW - Animals KW - Animals, Newborn KW - Cell Proliferation KW - Female KW - Heart Injuries/et [Etiology] KW - Heart Injuries/rh [Rehabilitation] KW - Male KW - Mice KW - MedStar Franklin Square Medical Center KW - Surgery KW - Journal Article N2 - Neonatal mouse hearts have a regenerative capacity similar to adult zebrafish. Different cardiac injury models have been established to investigate the regenerative capacity of neonatal mouse hearts, including ventricular amputation, cryoinjury, and ligation of a major coronary artery. While the ventricular resection model can be utilized to study how tissue forms and regenerates de novo, cryoinjury and coronary artery ligation are methods that might better mimic myocardial infarction by creating tissue damage and necrosis as opposed to the removal of healthy tissue in the ventricular amputation model. Here we describe methods of creating ventricular resection and cardiac cryoinjury in newborn mice UR - https://dx.doi.org/10.1007/978-1-0716-0668-1_2 ER -