TY  - BOOK
AU  - Ben-Dor, Itsik
AU  - Chen, Yuefeng
AU  - Dheendsa, Aaphtaab
AU  - Garcia-Garcia, Hector M
AU  - Hashim, Hayder
AU  - Khalid, Nauman
AU  - Mintz, Gary S
AU  - Musallam, Anees
AU  - Rogers, Toby
AU  - Shlofmitz, Evan
AU  - Waksman, Ron
AU  - Zhang, Cheng
TI  - Impact of intravascular ultrasound on Outcomes following PErcutaneous coronary interventioN for In-stent Restenosis (iOPEN-ISR study)
SN  - 0167-5273
PY  - 2021///
KW  - *Coronary Artery Disease
KW  - *Coronary Restenosis
KW  - *Drug-Eluting Stents
KW  - *Percutaneous Coronary Intervention
KW  - Coronary Angiography
KW  - Coronary Restenosis/dg [Diagnostic Imaging]
KW  - Coronary Restenosis/et [Etiology]
KW  - Humans
KW  - Percutaneous Coronary Intervention/ae [Adverse Effects]
KW  - Treatment Outcome
KW  - Ultrasonography, Interventional
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
N2  - BACKGROUND: Percutaneous coronary intervention (PCI) for in-stent restenosis (ISR) remains common. Intravascular imaging allows for the determination of the mechanism of ISR, potentially guiding appropriate therapy. Intravascular ultrasound (IVUS)-guided stent implantation is associated with a reduction in adverse events after PCI, but its impact on treatment of ISR is not clear; CONCLUSIONS: The use of IVUS is associated with decreased MACE at 1 year following PCI for ISR. These results support routine IVUS for the treatment of ISR lesions. Copyright (c) 2021. Published by Elsevier B.V; METHODS: All patients with 1-year follow-up after ISR treatment from 2003 through 2016 were included and stratified by IVUS use. The primary endpoint was the rate of major adverse cardiac events (MACE) at 1 year, defined as the composite of all-cause mortality, Q-wave myocardial infarction, and target vessel revascularization (TVR); RESULTS: The final analysis included 1522 ISR patients, 65.9% of whom were treated with IVUS guidance. The primary endpoint occurred in 18.0% of patients treated with IVUS guidance vs. 24.5% of patients treated with angiography guidance (p = 0.0014). Post-dilatation was used more often with IVUS (18.6% vs. 14.1%, p < 0.001), with a larger diameter of new stents (3.04 +/- 0.35 mm vs. 2.94 +/- 0.47 mm, p = 0.001). At 1 year, TVR occurred in 14.5% with IVUS guidance and 19.2% with angiography guidance (p = 0.021)
UR  - https://dx.doi.org/10.1016/j.ijcard.2021.08.003
ER  -