Brief topical sodium nitrite and its impact on the quality of life in patients with sickle leg ulcers.

MedStar author(s):
Citation: Medicine. 97(46):e12614, 2018 Nov.PMID: 30431560Institution: MedStar National Rehabilitation NetworkForm of publication: Journal ArticleMedline article type(s): Clinical Trial | Journal ArticleSubject headings: *Anemia, Sickle Cell/co [Complications] | *Leg Ulcer/dt [Drug Therapy] | *Patient Reported Outcome Measures | *Quality of Life | *Sodium Nitrite/ad [Administration & Dosage] | Administration, Topical | Adolescent | Adult | Female | Hematopoietic Stem Cell Transplantation | Humans | IN PROCESS -- NOT YET INDEXED | Leg Ulcer/et [Etiology] | Male | Middle Aged | Preoperative Period | Prospective Studies | Treatment Outcome | Wound Healing/de [Drug Effects] | Young AdultYear: 2018Local holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006ISSN:
  • 0025-7974
Name of journal: MedicineAbstract: Cutaneous ulceration from sickle cell disease negatively impacts quality of life. Topical sodium nitrite has previously been shown to reduce the size of sickle leg ulcers. This study examined how topical sodium nitrite impacted the quality of life scores in patients with sickle leg ulcers.We prospectively collected data in patients enrolled in a leg ulcer study (n = 17) or an allogeneic hematopoietic cell transplant study (nonulcer group, n = 15). Both groups completed a pretreatment Short Form-36 questionnaire; the ulcer group completed a second questionnaire after 4 weeks of topical sodium nitrite applications. Data were analyzed by age, sex, >50% area improvement postintervention, and sickle-related complications (vaso-occlusive crises, pulmonary hypertension, or avascular necrosis). Physical and mental component summary scores were analyzed with Student t test.Physical summary scores were lower than mental summary scores in all groups, indicating leg ulcers among other sickle related complications negatively impacted physical quality of life measures. After sodium nitrite use, physical summary scores improved in the leg ulcer group (34.5 +/- 9.4 to 39 +/- 10.3, P = .03), and mental summary scores improved more in ulcerated patients <=35 years old (40.7 +/- 6.9 to 51.7 +/- 9.7, P = .01).Brief topical sodium nitrite has the potential to improve quality of life, especially in younger individuals. Longer treatment duration and randomized-controlled trials are needed to confirm the efficacy of this topical therapy.All authors: Connor JL Jr, Hsieh MM, Kato GJ, Minniti CP, Sclafani JAFiscal year: FY2019Digital Object Identifier: Date added to catalog: 2018-12-14
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 30431560 Available 30431560

Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006

Cutaneous ulceration from sickle cell disease negatively impacts quality of life. Topical sodium nitrite has previously been shown to reduce the size of sickle leg ulcers. This study examined how topical sodium nitrite impacted the quality of life scores in patients with sickle leg ulcers.We prospectively collected data in patients enrolled in a leg ulcer study (n = 17) or an allogeneic hematopoietic cell transplant study (nonulcer group, n = 15). Both groups completed a pretreatment Short Form-36 questionnaire; the ulcer group completed a second questionnaire after 4 weeks of topical sodium nitrite applications. Data were analyzed by age, sex, >50% area improvement postintervention, and sickle-related complications (vaso-occlusive crises, pulmonary hypertension, or avascular necrosis). Physical and mental component summary scores were analyzed with Student t test.Physical summary scores were lower than mental summary scores in all groups, indicating leg ulcers among other sickle related complications negatively impacted physical quality of life measures. After sodium nitrite use, physical summary scores improved in the leg ulcer group (34.5 +/- 9.4 to 39 +/- 10.3, P = .03), and mental summary scores improved more in ulcerated patients <=35 years old (40.7 +/- 6.9 to 51.7 +/- 9.7, P = .01).Brief topical sodium nitrite has the potential to improve quality of life, especially in younger individuals. Longer treatment duration and randomized-controlled trials are needed to confirm the efficacy of this topical therapy.

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