Appendiceal tumors with glandular and neuroendocrine features exhibiting peritoneal metastases - Critical evaluation of outcome following cytoreductive surgery with perioperative chemotherapy. [Review]

MedStar author(s):
Citation: European Journal of Surgical Oncology. 47(6):1278-1285, 2021 Jun.PMID: 33500181Institution: MedStar Health Research Institute | Washington Cancer InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Adenocarcinoma/th [Therapy] | *Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use] | *Appendiceal Neoplasms/th [Therapy] | *Carcinoid Tumor/th [Therapy] | *Neoplasms, Complex and Mixed/th [Therapy] | *Peritoneal Neoplasms/th [Therapy] | Adenocarcinoma/co [Complications] | Adenocarcinoma/sc [Secondary] | Administration, Intravenous | Adult | Aged | Appendiceal Neoplasms/co [Complications] | Appendiceal Neoplasms/pa [Pathology] | Carcinoid Tumor/co [Complications] | Carcinoid Tumor/sc [Secondary] | Cytoreduction Surgical Procedures | Doxorubicin/ad [Administration & Dosage] | Female | Fluorouracil/ad [Administration & Dosage] | Humans | Hyperthermic Intraperitoneal Chemotherapy | Infusions, Parenteral | Leucovorin/ad [Administration & Dosage] | Male | Middle Aged | Mitomycin/ad [Administration & Dosage] | Neoadjuvant Therapy | Neoplasm Staging | Neoplasm, Residual | Neoplasms, Complex and Mixed/pa [Pathology] | Neuroendocrine Tumors | Perioperative Period | Peritoneal Neoplasms/co [Complications] | Peritoneal Neoplasms/sc [Secondary] | Prognosis | Survival Rate | Symptom AssessmentYear: 2021Local holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library:2002-2007ISSN:
  • 0748-7983
Name of journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical OncologyAbstract: BACKGROUND: A rare appendiceal malignancy is characterized by both glandular and neuroendocrine histology. It often presents with dissemination of the perforated tumor to peritoneal surfaces. Current treatments involve systemic chemotherapy, cytoreductive surgery and perioperative intraperitoneal chemotherapy.CONCLUSIONS: These data show that patients with a lesser extent of disease with a complete cytoreduction had an improved prognosis. No benefit from systemic or perioperative regional chemotherapy was apparent. With long-term follow-up, patients with the combined glandular and neuroendocrine histology exhibiting peritoneal metastases have a guarded prognosis. Copyright (c) 2021 Elsevier Ltd, BASO The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.METHODS: The impact of clinical, histological and treatment-related characteristics on survival were evaluated and subjected to univariate statistical analyses. All patients had stage IV disease and were treated by a uniform treatment strategy. Survival was determined from onset of disease until death or most recent follow-up.RESULTS: There were 47 patients available for study of whom 17 were male. Median age was 48 with a range of 27-65. None or a single symptom vs. 2 or more symptoms had a significant effect on survival. Median survival of the entire cohort was 45 months and 34.88% and 8.72% of patients survived 5 and 10 years, respectively. The use of neoadjuvant chemotherapy showed no impact on survival. Patients with a peritoneal cancer index (PCI) of 0-20 as compared to PCI > 20 survived longer (p = 0.012). The survival of patients able to have a complete resection as compared to an incomplete resection of disease was significant (p = 0.0087). The type of perioperative chemotherapy did not alter survival.All authors: Barrak D, Desale S, Dugan MM, Kodavanti PP, Sampah ME, Sugarbaker PH, Yoon JJOriginally published: European Journal of Surgical Oncology. 2021 Jan 21Fiscal year: FY2021Digital Object Identifier: Date added to catalog: 2021-02-17
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 33500181 Available 33500181

Available online from MWHC library: 1995 - present, Available in print through MWHC library:2002-2007

BACKGROUND: A rare appendiceal malignancy is characterized by both glandular and neuroendocrine histology. It often presents with dissemination of the perforated tumor to peritoneal surfaces. Current treatments involve systemic chemotherapy, cytoreductive surgery and perioperative intraperitoneal chemotherapy.

CONCLUSIONS: These data show that patients with a lesser extent of disease with a complete cytoreduction had an improved prognosis. No benefit from systemic or perioperative regional chemotherapy was apparent. With long-term follow-up, patients with the combined glandular and neuroendocrine histology exhibiting peritoneal metastases have a guarded prognosis. Copyright (c) 2021 Elsevier Ltd, BASO The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

METHODS: The impact of clinical, histological and treatment-related characteristics on survival were evaluated and subjected to univariate statistical analyses. All patients had stage IV disease and were treated by a uniform treatment strategy. Survival was determined from onset of disease until death or most recent follow-up.

RESULTS: There were 47 patients available for study of whom 17 were male. Median age was 48 with a range of 27-65. None or a single symptom vs. 2 or more symptoms had a significant effect on survival. Median survival of the entire cohort was 45 months and 34.88% and 8.72% of patients survived 5 and 10 years, respectively. The use of neoadjuvant chemotherapy showed no impact on survival. Patients with a peritoneal cancer index (PCI) of 0-20 as compared to PCI > 20 survived longer (p = 0.012). The survival of patients able to have a complete resection as compared to an incomplete resection of disease was significant (p = 0.0087). The type of perioperative chemotherapy did not alter survival.

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