Hydroconductive and silver-impregnated foam dressings: a comparison.

MedStar author(s):
Citation: Journal of Wound Care. 26(Sup7):S15-S22, 2017 Jul 01PMID: 28704172Institution: MedStar Health Research Institute | MedStar Washington Hospital CenterDepartment: Burn and Surgical Research LaboratoryForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Anti-Infective Agents, Local/pd [Pharmacology] | *Bandages | *Burns/th [Therapy] | *Methicillin-Resistant Staphylococcus aureus/de [Drug Effects] | *Silver/pd [Pharmacology] | *Staphylococcal Infections/th [Therapy] | *Wound Healing/de [Drug Effects] | *Wound Infection/th [Therapy] | Animals | Bacterial Toxins/me [Metabolism] | Burns/mi [Microbiology] | Enterotoxins/me [Metabolism] | In Vitro Techniques | Methicillin-Resistant Staphylococcus aureus/me [Metabolism] | Rats | Superantigens/de [Drug Effects] | Superantigens/me [Metabolism]Year: 2017ISSN:
  • 0969-0700
Name of journal: Journal of wound careAbstract: METHOD: A hydroconductive (HC) dressing and a silver-impregnated foam (SIF) dressing were compared for their potential to reduce the levels meticillin-resistant Staphylococcus aureus (MRSA). We also assessed MRSA-derived biologically active components in liquid or agar matrices, simplified models for heavily exuding or dry wounds respectively, and in an in vivo animal model with MRSA infected wounds.OBJECTIVE: As the number of commercially available wound dressings is increasing rapidly, it is important for clinicians to understand the strengths and limitations of each and to recognise relationships between wound type and dressing properties to obtain optimal healing results. Our aim is to test the antimicrobial activity of two dressings.RESULTS: In the agar model (dry wounds) both dressings showed a strong reduction in MRSA activities within 24 hours post-application. The antibacterial effects of the SIF dressing were more pronounced in the liquid model, however, at an increasing cytotoxic cost. In agreement with these in vitro results, assessment of dressings using an MRSA-infected wound in an rat model showed a decrease in MRSA which was significant 7 days post-burn and inoculation, with more compromised viability of MRSA. Dressings showed a similar capability to reduced and eliminate toxic shock syndrome toxin (TSST-1) at day 7 post-burn in the animal model but not at day 4, where the SIF dressing was more potent Conclusion: These results confirm the advantages of using silver in reducing bacterial load in wound treatment, except for conditions of highly exuding wounds where the cytotoxic properties of silver may offset these advantages and HC dressing use is more suitable.All authors: A A, A D, B C C, H N H, J W S, J Z, K W M, L T MFiscal year: FY2018Digital Object Identifier: Date added to catalog: 2017-07-24
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METHOD: A hydroconductive (HC) dressing and a silver-impregnated foam (SIF) dressing were compared for their potential to reduce the levels meticillin-resistant Staphylococcus aureus (MRSA). We also assessed MRSA-derived biologically active components in liquid or agar matrices, simplified models for heavily exuding or dry wounds respectively, and in an in vivo animal model with MRSA infected wounds.

OBJECTIVE: As the number of commercially available wound dressings is increasing rapidly, it is important for clinicians to understand the strengths and limitations of each and to recognise relationships between wound type and dressing properties to obtain optimal healing results. Our aim is to test the antimicrobial activity of two dressings.

RESULTS: In the agar model (dry wounds) both dressings showed a strong reduction in MRSA activities within 24 hours post-application. The antibacterial effects of the SIF dressing were more pronounced in the liquid model, however, at an increasing cytotoxic cost. In agreement with these in vitro results, assessment of dressings using an MRSA-infected wound in an rat model showed a decrease in MRSA which was significant 7 days post-burn and inoculation, with more compromised viability of MRSA. Dressings showed a similar capability to reduced and eliminate toxic shock syndrome toxin (TSST-1) at day 7 post-burn in the animal model but not at day 4, where the SIF dressing was more potent Conclusion: These results confirm the advantages of using silver in reducing bacterial load in wound treatment, except for conditions of highly exuding wounds where the cytotoxic properties of silver may offset these advantages and HC dressing use is more suitable.

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