Transcatheter Aortic Valve Replacement in Patients With Symptomatic Severe Aortic Stenosis and Prior External Chest Radiation.

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Citation: Cardiovascular Revascularization Medicine. 20(5):376-380, 2019 05.PMID: 31079816Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Aortic Valve Stenosis/su [Surgery] | *Aortic Valve/su [Surgery] | *Cancer Survivors | *Thorax/re [Radiation Effects] | *Transcatheter Aortic Valve Replacement | Aged | Aged, 80 and over | Aortic Valve Stenosis/dg [Diagnostic Imaging] | Aortic Valve Stenosis/mo [Mortality] | Aortic Valve Stenosis/pp [Physiopathology] | Aortic Valve/dg [Diagnostic Imaging] | Aortic Valve/pp [Physiopathology] | District of Columbia/ep [Epidemiology] | Female | Heart Block/ep [Epidemiology] | Heart Block/th [Therapy] | Hemodynamics | Humans | Length of Stay | Male | Middle Aged | Prevalence | Prospective Studies | Radiotherapy | Risk Factors | Severity of Illness Index | Time Factors | Transcatheter Aortic Valve Replacement/ae [Adverse Effects] | Transcatheter Aortic Valve Replacement/mo [Mortality] | Treatment OutcomeYear: 2019Local holdings: Available in print through MWHC library: 2002 - presentISSN:
  • 1878-0938
Name of journal: Cardiovascular revascularization medicine : including molecular interventionsAbstract: BACKGROUND/PURPOSE: Surgical aortic valve replacement (SAVR) in patients with symptomatic severe aortic stenosis (AS) and prior chest radiation is associated with poor outcomes in comparison with patients without prior radiation. Our objective was to compare clinical outcomes of patients with and without prior chest radiation undergoing transcatheter aortic valve replacement (TAVR) for symptomatic severe AS.CONCLUSIONS: Thus, TAVR appears to be a safe treatment option in the short and medium term for patients with symptomatic severe AS and prior chest radiation.Copyright (c) 2019. Published by Elsevier Inc.METHODS/MATERIALS: Between January 2003 and January 2017, 1150 patients underwent TAVR at our institution. Of these, 44 had prior chest radiation. Baseline demographic and clinical characteristics, procedural details, and clinical outcomes were prospectively collected.RESULTS: Patients with prior chest radiation were younger, 76+/-13years, compared with those without prior chest radiation, 82+/-8years (p=0.002). Median Society of Thoracic Surgeons score for chest radiation patients was 7+/-4, compared to 8+/-5 in those without prior radiation. Despite higher prevalence of complete heart block, there was no significant difference between the 2 groups with regard to the need for permanent pacemaker implantation. There was a trend toward longer length of intensive care unit stay in chest radiation patients, but there was no significant difference in 30-day or 1-year mortality.All authors: Attaran S, Ben-Dor I, Buchanan KD, Gajanana D, Iantorno M, Kolm P, Okubagzi PG, Rogers T, Satler LF, Thourani VH, Torguson R, Waksman R, Weintraub WS, Zhang COriginally published: Cardiovascular Revascularization Medicine. 20(5):376-380, 2019 May.Fiscal year: FY2019Digital Object Identifier: Date added to catalog: 2019-05-21
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 31079816 Available 31079816

Available in print through MWHC library: 2002 - present

BACKGROUND/PURPOSE: Surgical aortic valve replacement (SAVR) in patients with symptomatic severe aortic stenosis (AS) and prior chest radiation is associated with poor outcomes in comparison with patients without prior radiation. Our objective was to compare clinical outcomes of patients with and without prior chest radiation undergoing transcatheter aortic valve replacement (TAVR) for symptomatic severe AS.

CONCLUSIONS: Thus, TAVR appears to be a safe treatment option in the short and medium term for patients with symptomatic severe AS and prior chest radiation.

Copyright (c) 2019. Published by Elsevier Inc.

METHODS/MATERIALS: Between January 2003 and January 2017, 1150 patients underwent TAVR at our institution. Of these, 44 had prior chest radiation. Baseline demographic and clinical characteristics, procedural details, and clinical outcomes were prospectively collected.

RESULTS: Patients with prior chest radiation were younger, 76+/-13years, compared with those without prior chest radiation, 82+/-8years (p=0.002). Median Society of Thoracic Surgeons score for chest radiation patients was 7+/-4, compared to 8+/-5 in those without prior radiation. Despite higher prevalence of complete heart block, there was no significant difference between the 2 groups with regard to the need for permanent pacemaker implantation. There was a trend toward longer length of intensive care unit stay in chest radiation patients, but there was no significant difference in 30-day or 1-year mortality.

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