000			04010nam a22005897a 4500
008			160113s20142014 xxu||||| |||| 00| 0 eng d
022			_a0149-5992
040			_aOvid MEDLINE(R)
099			_a25024396
245			_aEffects of weight loss, weight cycling, and weight loss maintenance on diabetes incidence and change in cardiometabolic traits in the Diabetes Prevention Program.
251			_aDiabetes Care. 37(10):2738-45, 2014 Oct.
252			_aDiabetes Care. 37(10):2738-45, 2014 Oct.
253			_aDiabetes care
260			_c2014
260			_fFY2015
266			_d2016-01-13
501			_aAvailable online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
520			_aCONCLUSIONS: Two-year weight loss was the strongest predictor of reduced diabetes risk and improvements in cardiometabolic traits.Copyright � 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
520			_aOBJECTIVE: This study examined specific measures of weight loss in relation to incident diabetes and improvement in cardiometabolic risk factors.
520			_aRESEARCH DESIGN AND METHODS: This prospective, observational study analyzed nine weight measures, characterizing baseline weight, short- versus long-term weight loss, short- versus long-term weight regain, and weight cycling, within the Diabetes Prevention Program (DPP) lifestyle intervention arm (n = 1,000) for predictors of incident diabetes and improvement in cardiometabolic risk factors over 2 years.
520			_aRESULTS: Although weight loss in the first 6 months was protective of diabetes (hazard ratio [HR] 0.94 per kg, 95% CI 0.90, 0.98; P < 0.01) and cardiometabolic risk factors (P < 0.01), weight loss from 0 to 2 years was the strongest predictor of reduced diabetes incidence (HR 0.90 per kg, 95% CI 0.87, 0.93; P < 0.01) and cardiometabolic risk factor improvement (e.g., fasting glucose: beta = -0.57 mg/dL per kg, 95% CI -0.66, -0.48; P < 0.01). Weight cycling (defined as number of 5-lb [2.25-kg] weight cycles) ranged 0-6 times per participant and was positively associated with incident diabetes (HR 1.33, 95% CI 1.12, 1.58; P < 0.01), fasting glucose (beta = 0.91 mg/dL per cycle; P = 0.02), HOMA-IR (beta = 0.25 units per cycle; P = 0.04), and systolic blood pressure (beta = 0.94 mmHg per cycle; P = 0.01). After adjustment for baseline weight, the effect of weight cycling remained statistically significant for diabetes risk (HR 1.22, 95% CI 1.02, 1.47; P = 0.03) but not for cardiometabolic traits.
546			_aEnglish
650			_a*Cardiovascular Diseases/et [Etiology]
650			_a*Diabetes Mellitus/ep [Epidemiology]
650			_a*Diabetes Mellitus/et [Etiology]
650			_a*Metabolic Diseases/et [Etiology]
650			_a*Weight Loss/ph [Physiology]
650			_aAdult
650			_aBlood Glucose/me [Metabolism]
650			_aBody Weight/ph [Physiology]
650			_aCardiovascular Diseases/ep [Epidemiology]
650			_aDiabetes Mellitus/pc [Prevention & Control]
650			_aFemale
650			_aHumans
650			_aIncidence
650			_aLife Style
650			_aMale
650			_aMetabolic Diseases/ep [Epidemiology]
650			_aMiddle Aged
650			_aProspective Studies
650			_aRisk Factors
650			_aWeight Reduction Programs
651			_aMedStar Health Research Institute
657			_aJournal Article
657			_aObservational Study
657			_aResearch Support, N.I.H., Extramural
657			_aResearch Support, Non-U.S. Gov't
700			_aAroda, Vanita R
790			_aAroda VR, Bray GA, Delahanty LM, Diabetes Prevention Program Research Group, Florez JC, Franks PW, Jablonski KA, Kahn SE, Pan Q, Perreault L, Watson KE
856			_uhttp://dx.doi.org/10.2337/dc14-0018 _zhttp://dx.doi.org/10.2337/dc14-0018
942			_cART _dArticle
999			_c1024 _d1024