000			03827nam a22004817a 4500
008			210607s20212021 xxu||||| |||| 00| 0 eng d
022			_a0815-9319
024			_a10.1111/jgh.15430 [doi]
040			_aOvid MEDLINE(R)
099			_a33604947
245			_aDynamic changes in the pancreatitis activity scoring system during hospital course in a multicenter, prospective cohort.
251			_aJournal of Gastroenterology & Hepatology. 36(9):2416-2423, 2021 Sep.
252			_aJ Gastroenterol Hepatol. 36(9):2416-2423, 2021 Sep.
252			_zJ Gastroenterol Hepatol. 2021 Feb 18
253			_aJournal of gastroenterology and hepatology
260			_c2021
260			_fFY2021
265			_sppublish
266			_d2021-03-10
268			_aJournal of Gastroenterology & Hepatology. 2021 Feb 18
520			_aBACKGROUND AND AIM: The primary aim was to validate the Pancreatitis Activity Scoring System (PASS) in a multicenter prospectively ascertained acute pancreatitis (AP) cohort. Second, we investigated the association of early PASS trajectories with disease severity and length of hospital stay (LOS).
520			_aCONCLUSIONS: This study highlighted that PASS can quantify AP activity. Significant differences in PASS trajectories were found both in revised Atlanta classification severity and LOS groups, which can be harnessed in AP monitoring/management (ClincialTrials.gov number, NCT03075618). Copyright (c) 2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.
520			_aMETHODS: Data were prospectively collected through the APPRENTICE consortium (2015-2018). AP severity was categorized based on revised Atlanta classification. Delta PASS (DELTAPASS) was calculated by subtracting activity score from baseline value. PASS trajectories were compared between severity subsets. Subsequently, the cohort was subdivided into three LOS subgroups as short (S-LOS): 2-3 days; intermediate (I-LOS): 3-7 days; and long (L-LOS): >=7 days. The generalized estimating equations model was implemented to compare PASS trajectories.
520			_aRESULTS: There were 434 subjects analyzed including 322 (74%) mild, 86 (20%) moderately severe, and 26 (6%) severe AP. Severe AP subjects had the highest activity levels and the slowest rate of decline in activity (P = 0.039). Focusing on mild AP, L-LOS subjects (34%) had 28 points per day slower decline; whereas, S-LOS group (13%) showed 34 points per day sharper decrease compared with I-LOS (53%; P < 0.001). We noticed an outlier subset with a median admission-PASS of 466 compared with 140 in the rest. Morphine equivalent dose constituted 80% of the total PASS in the outliers (median morphine equivalent dose score = 392), compared with only 25% in normal-range subjects (score = 33, P value < 0.001).
546			_aEnglish
650			_a*Pancreatitis
650			_a*Severity of Illness Index
650			_aAcute Disease
650			_aHospitalization
650			_aHumans
650			_aMorphine Derivatives
650			_aPancreatitis/pp [Physiopathology]
650			_aPancreatitis/th [Therapy]
650			_aProspective Studies
651			_aMedStar Washington Hospital Center
656			_aInternal Medicine Residency
657			_aJournal Article
700			_aPothoulakis, Ioannis
790			_aAkshintala V, Buxbaum JL, Conwell D, Cote GA, Easler JJ, Gougol A, Greer PJ, Hart P, Kamal A, Lee PJ, Machicado JD, Nawaz H, Papachristou GI, Paragomi P, Phillips AE, Pothoulakis I, Singh VK, Stevens T, Tang G, Thakkar S, Tuft M, Whitcomb DC, Wu BU
856			_uhttps://dx.doi.org/10.1111/jgh.15430 _zhttps://dx.doi.org/10.1111/jgh.15430
858			_yParagomi, Pedram _uhttps://orcid.org/0000-0002-5471-4979 _zhttps://orcid.org/0000-0002-5471-4979
942			_cART _dArticle
999			_c11218 _d11218