000			02924nam a22004097a 4500
008			230411s20232023 xxu||||| |||| 00| 0 eng d
022			_a0271-678X
024			_a10.1177/0271678X231155222 [doi]
040			_aOvid MEDLINE(R)
099			_a36748316
245			_aPost-ischemic hyperemia following endovascular therapy for acute stroke is associated with lesion growth.
251			_aJournal of Cerebral Blood Flow & Metabolism. :271678X231155222, 2023 Feb 07
252			_aJ Cereb Blood Flow Metab. :271678X231155222, 2023 Feb 07
253			_aJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
260			_c2023
260			_fFY2023
260			_p2023 Feb 07
265			_saheadofprint
265			_tPublisher
266			_d2023-04-11
520			_aA substantial proportion of acute stroke patients fail to recover following successful endovascular therapy (EVT) and injury to the brain and vasculature secondary to reperfusion may be a contributor. Acute stroke patients were included with: i) large vessel occlusion of the anterior circulation, ii) successful recanalization, and iii) evaluable MRI early after EVT. Presence of hyperemia on MRI perfusion was assessed by consensus using a modified ASPECTS. Three different approaches were used to quantify relative cerebral blood flow (rCBF). Sixty-seven patients with median age of 66 [59-76], 57% female, met inclusion criteria. Hyperemia was present in 35/67 (52%) patients early post-EVT, in 32/65 (49%) patients at 24 hours, and in 19/48 (40%) patients at 5 days. There were no differences in incomplete reperfusion, HT, PH-2, HARM, severe HARM or symptomatic ICH rates between those with and without early post-EVT hyperemia. A strong association (R2 = 0.81, p < 0.001) was found between early post-EVT hyperemia (p = 0.027) and DWI volume at 24 hours after adjusting for DWI volume at 2 hours (p < 0.001) and incomplete reperfusion at 24 hours (p = 0.001). Early hyperemia is a potential marker for cerebrovascular injury and may help select patients for adjunctive therapy to prevent edema, reperfusion injury, and lesion growth.
546			_aEnglish
650			_aIN PROCESS -- NOT YET INDEXED
651			_aMedStar Washington Hospital Center
656			_aNeurology
656			_aNursing
657			_aJournal Article
700			_aBurton, Shannon _bMWHC
700			_aCabatbat, Rainier
700			_aCraft, Veronica _bMWHC
700			_aHsia, Amie W _bMWHC
700			_aKim, Yongwoo _bMWHC
700			_aUche, Victoria _bMWHC
790			_aLuby M, Hsia AW, Lomahan CA, Davis R, Burton S, Kim Y, Craft V, Uche V, Cabatbat R, Adil MM, Thomas LC, De Vis JB, Afzal MM, McGavern D, Lynch JK, Leigh R, Latour LL
856			_uhttps://dx.doi.org/10.1177/0271678X231155222 _zhttps://dx.doi.org/10.1177/0271678X231155222
942			_cART _dArticle
999			_c11643 _d11643