000			03438nam a22004817a 4500
008			130912s20122012 xxu||||| |||| 00| 0 eng dOvid Technologies
022			_a0022-3166
040			_aOvid MEDLINE(R)
099			_a22190026
245			_aDietary patterns are associated with disease risk among participants in the Women's Health Initiative Observational Study.
251			_aJournal of Nutrition. 142(2):284-91, 2012 Feb.
252			_aJ Nutr. 142(2):284-91, 2012 Feb.
253			_aThe Journal of nutrition
266			_d2013-09-17
501			_aAvailable online from MWHC library: Sept 1928 - present (after 1 year)
520			_aCoronary heart disease (CHD) is the leading cause of death in women. A nested case-control study tested whether dietary patterns predicted CHD events among 1224 participants in the Women's Health Initiative-Observational Study (WHI-OS) with centrally confirmed CHD, fatal or nonfatal myocardial infarct compared to 1224 WHI-OS controls matched for age, enrollment date, race/ethnicity, and absence of CHD at baseline or follow-up. The first six principal components explained >75% of variation in dietary intakes and K-mean analysis based on these six components produced three clusters. Diet cluster 1 was rich in carbohydrate, vegetable protein, fiber, dietary vitamin K, folate, carotenoids, -linolenic acid [18:3(n-3)], linoleic acid [18:2(n-6)], and supplemental calcium and vitamin D. Diet cluster 2 was rich in total and animal protein, arachidonic acid [20:4(n-6)], DHA [22:6(n-3)], vitamin D, and calcium. Diet cluster 3 was rich in energy, total fat, and trans fatty acids (all P < 0.01). Conditional logistic regression analysis demonstrated diet cluster 1 was associated with lower CHD risk than diet cluster 2 (reference group) adjusted for smoking, education, and physical activity [OR = 0.79 (95% CI = 0.64, 0.99); P = 0.038]. This difference was not significant after adjustment for BMI and systolic blood pressure. Diet cluster 3 was associated with higher CHD risk than diet cluster 2 [OR = 1.28 (95% CI = 1.04, 1.57); P = 0.019], but this difference did not remain significant after adjustment for smoking, education, and physical activity. Within this WHI-OS cohort, distinct dietary patterns may be associated with subsequent CHD outcomes.
546			_aEnglish
650			_a*Coronary Disease/et [Etiology] _9884
650			_a*Diet/ae [Adverse Effects] _9885
650			_a*Food Habits _9887
650			_a*Women's Health _9890
650			_aAged _92
650			_aAging _9881
650			_aCase-Control Studies _9765
650			_aCluster Analysis _9882
650			_aCoronary Disease/ep [Epidemiology] _9883
650			_aEthnic Groups _9886
650			_aFemale _97
650			_aHumans _911
650			_aLogistic Models _9262
650			_aMiddle Aged _915
650			_aOdds Ratio _9456
650			_aPrincipal Component Analysis _9888
650			_aRisk Factors _9311
650			_aWomen's Health/sn [Statistics & Numerical Data] _9889
651			_aMedStar Health Research Institute
657			_aJournal Article
657			_aResearch Support, N.I.H., Extramural
700			_aHoward, Barbara V _9398
790			_aEaton CB, Horn LV, Howard BV, Lichtenstein AH, Matthan NR, Neuhouser ML, Snetselaar L, Tian L
856			_uhttp://dx.doi.org/10.3945/jn.111.145375 _zhttp://dx.doi.org/10.3945/jn.111.145375
942			_cART _dJournal article _2z
999			_c11968 _d11968