000			03360nam a22004337a 4500
008			230626s20232023 xxu||||| |||| 00| 0 eng d
022			_a2571-841X
024			_a10.3390/reports5040041 [doi]
024			_aNIHMS1871544 [mid]
024			_aPMC10104440 [pmc]
040			_aOvid MEDLINE(R)
099			_a37063094
245			_aCOVID-19 Outcomes in a US Cohort of Persons Living with HIV (PLWH).
251			_aReports (MDPI). 5(4), 2022 Dec.
252			_aReports (MDPI). 5(4), 2022 Dec.
253			_aReports (MDPI)
260			_c2022
260			_fFY2023
260			_p2022 Dec
265			_sppublish
265			_tPubMed-not-MEDLINE
266			_d2023-06-26
520			_aReported coronavirus disease 2019 (COVID-19) outcomes in persons living with HIV (PLWH) vary across cohorts. We examined clinical characteristics and outcomes of PLWH with COVID-19 compared with a matched HIV-seronegative cohort in a mid-Atlantic US healthcare system. Multivariate logistic regression was used to explore factors associated with hospitalization and death/mechanical ventilation among PLWH. Among 281 PLWH with COVID-19, the mean age was 51.5 (SD 12.74) years, 63% were male, 86% were Black, and 87% had a HIV viral load <200 copies/mL. Overall, 47% of PLWH versus 24% (p < 0.001) of matched HIV-seronegative individuals were hospitalized. Rates of COVID-19 associated cardiovascular and thrombotic events, AKI, and infections were similar between PLWH and HIV-seronegative individuals. Overall mortality was 6% (n = 18/281) in PLWH versus 3% (n = 33/1124) HIV-seronegative, p < 0.0001. Among admitted patients, mortality was 14% (n = 18/132) for PLWH and 13% (n = 33/269) for HIV-seronegative, p = 0.75. Among PLWH, hospitalization associated with older age aOR 1.04 (95% CI 1.01, 1.06), Medicaid insurance aOR 2.61 (95% CI 1.39, 4.97) and multimorbidity aOR 2.98 (95% CI 1.72, 5.23). Death/mechanical ventilation associated with older age aOR 1.06 (95% CI 1.01, 1.11), Medicaid insurance aOR 3.6 (95% CI 1.36, 9.74), and multimorbidity aOR 4.4 (95% CI 1.55, 15.9) in adjusted analyses. PLWH were hospitalized more frequently than the HIV-seronegative group and had a higher overall mortality rate, but once hospitalized had similar mortality rates. Older age, multimorbidity and insurance status associated with more severe outcomes among PLWH suggesting the importance of targeted interventions to mitigate the effects of modifiable inequities.
546			_aEnglish
650			_zAutomated
651			_aMedStar Health Research Institute
656			_aInfectious Diseases Fellowship
656			_aMedStar Georgetown University Hospital/MedStar Washington Hospital Center
657			_aJournal Article
700			_aDesale, Sameer _bMHRI
700			_aFernandez, Stephen _bMHRI
700			_aHuang, Xu _bMHRI
700			_aLee, Jennifer _bMGUH _cInfectious Diseases Fellowship _dMD _eAlumni
790			_aSpence AB, Desale S, Lee J, Kumar P, Huang X, Cooper SE, Fernandez S, Kassaye SG
856			_uhttps://dx.doi.org/10.3390/reports5040041 _zhttps://dx.doi.org/10.3390/reports5040041
858			_yHuang, Xu _uhttps://orcid.org/0000-0001-9108-5115 _zhttps://orcid.org/0000-0001-9108-5115
858			_yFernandez, Stephen _uhttps://orcid.org/0000-0002-5112-1844 _zhttps://orcid.org/0000-0002-5112-1844
942			_cART _dArticle
999			_c12580 _d12580