000			02959nam a22003497a 4500
008			230628s20232023 xxu||||| |||| 00| 0 eng d
022			_a0935-9648
024			_a10.1002/adma.202212190 [doi]
040			_aOvid MEDLINE(R)
099			_a36965107
245			_aGraphene Biointerface for Cardiac Arrhythmia Diagnosis and Treatment.
251			_aAdvanced Materials. :e2212190, 2023 Mar 25
252			_aAdv. mater.. :e2212190, 2023 Mar 25
253			_aAdvanced materials (Deerfield Beach, Fla.)
260			_c2023
260			_fFY2023
260			_p2023 Mar 25
265			_saheadofprint
265			_tPublisher
266			_d2023-06-28
520			_aHeart rhythm disorders, known as arrhythmias, cause significant morbidity and are one of the leading causes of mortality. Cardiac arrhythmias are frequently treated by implantable devices, such as pacemakers and defibrillators, or by ablation therapy guided by electroanatomical mapping. Both implantable and ablation therapies require sophisticated biointerfaces for electrophysiological measurements of electrograms and delivery of therapeutic stimulation or ablation energy. In this work, a graphene biointerface for in vivo cardiac electrophysiology is reported for the first time. Leveraging sub-micrometer-thick tissue-conformable graphene arrays, sensing and stimulation of the open mammalian heart are demonstrated both in vitro and in vivo. Furthermore, the graphene biointerface treatment of atrioventricular block (the kind of arrhythmia where the electrical conduction from the atria to the ventricles is interrupted) is demonstrated. The graphene arrays show effective electrochemical properties, namely interface impedance down to 40 OMEGA cm2 at 1 kHz, charge storage capacity up to 63.7 mC cm-2 , and charge injection capacity up to 704 microC cm-2 . Transparency of the graphene structures allows for simultaneous optical mapping of cardiac action potentials, calcium transients, and optogenetic stimulation while performing electrical measurements and stimulation. The report presents evidence of the significant potential of graphene biointerfaces for advanced cardiac electrophysiology and arrhythmia therapy. Copyright � 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.
546			_aEnglish
650			_aIN PROCESS -- NOT YET INDEXED
650			_zAutomated
656			_aAnesthesiology Residency
657			_aJournal Article
700			_aLaPiano, Jessica _bMGUH _cAnesthesiology Residency _dMD _eResident PGY 1{}e=656 \\ _aMedStar Georgetown University Hospital/MedStar Washington Hospital Center
790			_aAkinwande D, Chen Z, Efimov IR, Gupta S, Kireev D, LaPiano J, Lin Z, Liu N, Obaid SN
856			_uhttps://dx.doi.org/10.1002/adma.202212190 _zhttps://dx.doi.org/10.1002/adma.202212190
858			_zhttps://orcid.org/0000-0002-7093-359X _yLaPiano, Jessica _uhttps://orcid.org/0000-0002-7093-359X
942			_cART _dArticle
999			_c12938 _d12938