000			03935nam a22005417a 4500
008			130913s20122012 xxu||||| |||| 00| 0 eng dOvid Technologies
022			_a1876-4789
040			_aOvid MEDLINE(R)
099			_a22385551
245			_aThe relationship between subclinical atherosclerosis, non-high-density lipoprotein cholesterol, exercise, anddiet among male participants of the PACC Project.
251			_aJournal of Clinical Lipidology. 6(2):174-9, 2012 Mar-Apr.
252			_aJ. clin. lipidol.. 6(2):174-9, 2012 Mar-Apr.
253			_aJournal of clinical lipidology
260			_c2012
260			_fFY2012
266			_d2013-09-17
520			_aBACKGROUND: Non-high-density lipoprotein (HDL) cholesterol is recommended as a secondary lipid goal treated initially with lifestyle modification. However, the relationship between non-HDL and subclinical atherosclerosis is unknown. We examined the independent relationships between coronary artery calcium (CAC), lipids including non-HDL, exercise, and diet among healthy male participants of the Prospective Army Coronary Calcium (PACC) Project.
520			_aCONCLUSIONS: Non-HDL-C and exercise are independently predictive of the presence of subclinical CAC among healthy lower-risk middle-aged men. Copyright A 2012 National Lipid Association. All rights reserved.
520			_aMETHODS: Male participants from the PACC Project (n= 1637, mean age 42.8 years; no history of coronary heart disease) were studied. We used validated surveys to measure dietary quality and habitual physical exercise. Fasting lipid concentrations and other cardiovascular risk variables were measured. Subclinical atherosclerosis was detected with the use of electron beam computed tomography for CAC. Factors independently associated with the presence of any detectable CAC (CAC score > 0), including standard CV risk variables, non-HDL, exercise, and diet, were evaluated with the use of logistic regression.
520			_aRESULTS: The mean Framingham risk score was 4.6 +/- 2.6%; CAC was present in 22.4%. Fasting lipid concentrations showed mean LDL-C 128 +/- 32 mg/dL, HDL-C 50 +/- 13 mg/dL, TG-C 130 +/- 86 mg/dL, and non-HDL-C 154 +/- 37 mg/dL. Men with CAC had significantly greater levels of LDL-C (135 vs 127 mg/dL), TG (148 vs 124 mg/dL), and non-HDL-C (164 vs 151 mg/dL) and less habitual physical activity (P= 0.006). There were nonsignificant trends between prevalent CAC, greater amounts of dietary fat intake, and lower HDL-C. In successive multivariable logistic regression models for the dependent variable CAC, only non-HDL-C (odds ratio [OR] 1.012 per mg/dL; 95% CI 1.002-1.023; P= .019) and age (OR 1.119 per year; 95% CI 1.063-1.178; P < .001) were independently associated with the presence of CAC, and exercise (OR 0.808; 95% CI 0.703-0.928; P= 0.003) was associated with the absence of CAC.
546			_aEnglish
650			_a*Atherosclerosis/bl [Blood]
650			_a*Calcium/me [Metabolism]
650			_a*Cholesterol/bl [Blood]
650			_a*Coronary Vessels/me [Metabolism]
650			_a*Diet
650			_a*Exercise
650			_a*Military Personnel
650			_aAdult
650			_aAtherosclerosis/me [Metabolism]
650			_aAtherosclerosis/pp [Physiopathology]
650			_aHumans
650			_aLogistic Models
650			_aMale
650			_aMiddle Aged
650			_aProspective Studies
651			_aMedStar Health Research Institute
651			_aMedStar Heart & Vascular Institute
657			_aClinical Trial
657			_aJournal Article
657			_aResearch Support, Non-U.S. Gov't
657			_aResearch Support, U.S. Gov't, Non-P.H.S.
700			_aSimprini, Lauren A
700			_aTaylor, Allen J
790			_aRich M, Simprini LA, Taylor AJ, Villines TC
856			_uhttp://dx.doi.org/10.1016/j.jacl.2011.11.005 _zhttp://dx.doi.org/10.1016/j.jacl.2011.11.005
942			_cART _dArticle
999			_c1323 _d1323