000			02760nam a22003737a 4500
008			2401116s20232023 xxu||||| |||| 00| 0 eng d
022			_a2694-1902
024			_a10.3171/CASE23302 [doi]
024			_aCASE23302 [pii]
024			_aPMC10664628 [pmc]
040			_aOvid MEDLINE(R)
099			_a37992309
245			_aCervical corpectomy in a pediatric patient with chondrodysplasia punctata and C5 dysplasia with spinal cord compression: illustrative case.
251			_aJournal of Neurosurgery Case Lessons. 6(21), 2023 Nov 20.
252			_aJ. neurosurg., Case lessons. 6(21), 2023 Nov 20.
253			_aJournal of neurosurgery. Case lessons
260			_c2023
260			_fFY2024
260			_p2023 Nov 20
265			_sepublish
265			_tPubMed-not-MEDLINE
266			_d2024-01-16
520			_aBACKGROUND: Chondrodysplasia punctata (CDP) describes skeletal dysplasia secondary to a variety of genetic underpinnings characterized by cartilaginous stippling from abnormal calcium deposition during endochondral bone formation. Approximately 20%-38% of patients with CDP have cervical spine abnormalities, resulting in stenosis and cord compression. However, approaches to management differ among patients.
520			_aLESSONS: Despite many CDP patients having cervical deformities with spinal cord compression and associated neurological symptoms, there is a paucity of data on surgical management and outcomes. There are only scattered reports, and most authors recommend initial conservative management because of the high risk of operative morbidity and mortality secondary to comorbidities. When surgery is performed, long-term follow-up is recommended because of the high rates of progression of deformity, requiring subsequent operations. The authors hope that their experience adds to the literature describing the surgical management of cervical deformities in these patients.
520			_aOBSERVATIONS: The authors present an 18-year-old male with a known history of CDP and cervical kyphosis with worsening paresthesias and increased spasticity. Imaging confirmed dysplastic C4 and C5 vertebra with focal kyphosis, bony retropulsion, spinal cord compression, and myelomalacia. To treat the stenosis and deformity, the patient underwent C4 and C5 vertebrectomies with C3 to C6 anterior fusion with resolution of symptoms.
546			_aEnglish
656			_aMedStar Georgetown University Hospital/MedStar Washington Hospital Center
656			_aNeurosurgery Residency
657			_aJournal Article
700			_aPatel, Nirali _bMGUH _cNeurosurgery Residency _dMD
790			_aPatel NP, Youngblood MW, LoPresti MA, Alden TD
856			_uhttps://dx.doi.org/10.3171/CASE23302
942			_cART _dArticle
999			_c13702 _d13702