000			03559nam a22004697a 4500
008			2401116s20232023 xxu||||| |||| 00| 0 eng d
022			_a2397-9070
024			_a10.1002/jgh3.12942 [doi]
024			_aJGH312942 [pii]
024			_aPMC10615170 [pmc]
040			_aOvid MEDLINE(R)
099			_a37908288
245			_aEsophageal squamous papilloma: Literature review and case-control retrospective study with histopathological exam of human papillomavirus.
251			_aJgh Open. 7(10):674-681, 2023 Oct.
252			_aJGH open. 7(10):674-681, 2023 Oct.
253			_aJGH open : an open access journal of gastroenterology and hepatology
260			_c2023
260			_fFY2024
260			_p2023 Oct
265			_sepublish
265			_tPubMed-not-MEDLINE
266			_d2024-01-16
520			_aBackground and Aim: Esophageal squamous papilloma (ESP) is a benign growth in the esophagus with unknown malignant potential. The mechanism underlying ESP formation is unknown, but human papillomavirus (HPV) infection has been proposed as a potential etiology. We sought to investigate the clinical characteristic of ESP in our population, review the current literature, and highlight the role of HPV.
520			_aConclusions: We observed a higher prevalence of ESP compared to previous studies. The formation of ESP is multifactorial and partially explained by HPV infection in selected populations. The malignant potential of ESP is low but not negligible. Copyright © 2023 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.
520			_aMethods: This is a retrospective case-control study conducted at two referral centers. We selected the ESP population by free-text search in the pathology department database and selected controls randomly from the general endoscopy population. Immunostains were used to evaluate ESP tissue for HPV.
520			_aResults: Between January 2016 and December 2021, we identified 66 patients with ESP, with a prevalence of 0.72%. ESP patients were younger, with a median age of 52 years (P = 0.021), and more likely African American (34.4 vs 7.5%, P < 0.001) compared to controls. On endoscopy images, the growth was predominantly solitary (92.5%) in the middle of the esophagus (39.4%), with sizes ranging from 0.2 to 2.3 cm. A total of 62 patients had available tissue for HPV immune staining, and none tested positive for HPV. Eighteen patients had a follow-up endoscopy with an average of 504.5 days follow-up period. One patient developed esophageal squamous cell carcinoma during follow-up.
546			_aEnglish
651			_aMedStar Washington Hospital Center
656			_aInternal Medicine Residency
656			_aMedStar Georgetown University Hospital/MedStar Washington Hospital Center
656			_aPathology Residency
657			_aJournal Article
700			_aAhmad, Akram _bMWHC _cInternal Medicine Residency _dMBBS
700			_aAltork, Nadera _bMWHC _cInternal Medicine Residency _dMD
700			_aAlzraikat, Sayel _bMWHC _cInternal Medicine Residency _dMD
700			_aAyaz, Omair _bMWHC _cInternal Medicine Residency _dMBBS
700			_aNithagon, Pichayut _bMGUH _cPathology Residency _dMD
700			_aPeppas, Spyros _bMWHC _cInternal Medicine Residency _dMD
790			_aAhmad AI, Lee A, Nithagon P, Ayaz O, Altork N, Peppas S, Alzraikat S, Ayoubi R, Smith A, Dhanjal R, Jassal A, Rizzo SM, Cho WK
856			_uhttps://dx.doi.org/10.1002/jgh3.12942
942			_cART _dArticle
999			_c13782 _d13782