000			03683nam a22004937a 4500
008			240723s20242024 xxu||||| |||| 00| 0 eng d
022			_a1878-0938
024			_aS1553-8389(24)00109-X [pii]
040			_aOvid MEDLINE(R)
099			_a38631936
245			_aCoronary Microvascular Disease Registry (CMDR): Study design and rationale.
251			_aCardiovascular Revascularization Medicine. 2024 Mar 27
252			_aCardiovasc Revasc Med. 2024 Mar 27
253			_aCardiovascular revascularization medicine : including molecular interventions
260			_c2024
260			_p2024 Mar 27
265			_saheadofprint
265			_tPublisher
266			_d2024-07-23
501			_aAvailable in print through MWHC library: 2002 - present
520			_aBACKGROUND: Coronary microvascular dysfunction (CMD) is a prevalent condition among patients with cardiovascular risk factors, leading to a reduced quality of life and an increased risk of major adverse cardiovascular events. Novel invasive techniques have emerged to more accurately diagnose CMD. However, CMD's natural history remains poorly understood due to limited data. To address this knowledge gap, the Coronary Microvascular Disease Registry (CMDR) was established with the primary aim of standardizing comprehensive coronary functional testing and understanding of CMD.
520			_aCLINICAL TRIAL REGISTRATION: clinicaltrials.gov, NCT05960474. Copyright © 2024. Published by Elsevier Inc.
520			_aDESIGN: CMDR is a prospective, multicenter registry enrolling an unlimited number of consecutive subjects who undergo comprehensive invasive hemodynamic assessment of the entire coronary arterial vasculature. Patients undergoing acetylcholine provocation test for coronary vasospasm will also be included. Follow-up assessments will be conducted at 30 days and annually for up to 5 years. The primary endpoint is Canadian Cardiovascular Society angina grade over time. Secondary endpoints, including all-cause mortality, cardiovascular death, acute myocardial infarction, stroke, hospitalizations, medication changes, and subsequent coronary interventions, will be analyzed to establish long-term safety and clinical outcomes in patients undergoing invasive CMD assessment.
520			_aSUMMARY: CMDR aims to characterize the clinical and physiologic profile of patients undergoing comprehensive invasive coronary functional testing, simultaneously providing crucial longitudinal information on the natural history and outcomes of these patients. This will shed light on CMD's course and clinical implications, which, in turn, holds the potential to significantly improve diagnostic and treatment strategies for CMD patients, ultimately leading to the enhancement of their overall prognosis and quality of life.
546			_aEnglish
650			_zAutomated
650			_aIN PROCESS -- NOT YET INDEXED
651			_aMedStar Heart & Vascular Institute
657			_aJournal Article
700			_aBen-Dor, Itsik _bMHVI
700			_aCase, Brian C _bMHVI
700			_aGarcia Garcia, Hector M _bMHVI
700			_aHashim, Hayder _bMHVI
700			_aMedranda, Giorgio _bMHVI
700			_aMerdler, Ilan _bMHVI
700			_aOzturk, Sevket Tolga _bMHVI
700			_aSatler, Lowell F _bMHVI
700			_aSawant, Vaishnavi _bMHVI
700			_aWaksman, Ron _bMHVI
700			_aZhang, Cheng _bMHVI
790			_aCase BC, Merdler I, Medranda GA, Zhang C, Ozturk ST, Sawant V, Garcia-Garcia HM, Satler LF, Ben-Dor I, Hashim HD, Waksman R
856			_uhttps://dx.doi.org/10.1016/j.carrev.2024.03.021 _zhttps://dx.doi.org/10.1016/j.carrev.2024.03.021
942			_cART _dArticle
999			_c14171 _d14171