| 000 | 03642nam a22003737a 4500 | ||
|---|---|---|---|
| 008 | 240723s20242024 xxu||||| |||| 00| 0 eng d | ||
| 022 | _a1547-5646 | ||
| 040 | _aOvid MEDLINE(R) | ||
| 099 | _a38608299 | ||
| 245 | _aBiomarkers related to hypertrophy of the ligamentum flavum: a systematic review of the literature. | ||
| 251 | _aJournal of Neurosurgery Spine. :1-13, 2024 Apr 12 | ||
| 252 | _aJ Neurosurg Spine. :1-13, 2024 Apr 12 | ||
| 253 | _aJournal of neurosurgery. Spine | ||
| 260 | _c2024 | ||
| 260 | _p2024 Apr 12 | ||
| 265 | _saheadofprint | ||
| 265 | _tPublisher | ||
| 266 | _d2024-07-23 | ||
| 501 | _aAvailable online from MWHC library: 1999 - present, Available in print through MWHC library: 1999 - 2006 | ||
| 520 | _aCONCLUSIONS: Biomarkers such as TGF-beta, IL-6, and collagen I and III have been consistently correlated with the development of HLF. However, the pathogenesis of HLF remains unclear due to the heterogeneity of the studies, patient populations, and research at the molecular level. Further studies are necessary to better characterize the pathogenesis of HLF and provide a more comprehensive understanding of how these biomarkers may aid in the diagnosis and treatment of HLF. | ||
| 520 | _aMETHODS: A literature search was conducted using PubMed, Embase, Web of Science, and Cochrane Library. The search strategy looked for the titles, abstracts, and keywords of studies that contained a combination of the following phrases: "ligamentum flavum OR yellow ligament," "biomarkers," and "hypertrophy." Recorded data included study design, demographic characteristics (number of patients of each gender and mean age), study period, country where the study was conducted, biomarkers, and diagnostic modalities used. Risk of bias was assessed using the Newcastle-Ottawa Scale for case-control studies. | ||
| 520 | _aOBJECTIVE: Spinal stenosis is one of the most common spinal disorders in the elderly. Hypertrophy of the ligamentum flavum (HLF) can contribute to spinal stenosis. The current literature suggests that various biomarkers may play important roles in the pathogenesis of HLF. However, the connection between these biomarkers and the development of HLF is still not well understood. This systematic review aims to explore the current literature on biomarkers related to the development of HLF. | ||
| 520 | _aRESULTS: The authors identified 39 studies. After screening, 26 full-text original articles assessing one or more biomarkers related to HLF were included. The included studies were conducted over a 22-year period. The most popular biomarkers studied, in order of frequency reported, were collagen types I and III (n = 10), transforming growth factor beta (TGF-beta) (n = 8), and interleukin (IL)-6 (n = 6). The authors found that mechanical stretching forces, tissue inhibitor of metalloproteinases 2 (TIMP-2) induction, and TGF-beta were associated with increased amounts of collagen I and III. IL-6 expression was increased by microRNA-21, as well as by leptin, through the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) pathway. | ||
| 546 | _aEnglish | ||
| 650 | _zAutomated | ||
| 650 | _aIN PROCESS -- NOT YET INDEXED | ||
| 656 | _aMedStar Georgetown University Hospital/MedStar Washington Hospital Center | ||
| 656 | _aNeurosurgery Residency | ||
| 657 | _aJournal Article | ||
| 700 |
_aChesney, Kelsi _bMGUH _cNeurosurgery Residency _dMD |
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| 790 | _aMualem W, Liu J, Balu A, Chesney K, Nair MN | ||
| 856 |
_uhttps://dx.doi.org/10.3171/2024.2.SPINE23991 _zhttps://dx.doi.org/10.3171/2024.2.SPINE23991 |
||
| 942 |
_cART _dArticle |
||
| 999 |
_c14177 _d14177 |
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