| 000 | 02466nam a22003617a 4500 | ||
|---|---|---|---|
| 008 | 240723s20242024 xxu||||| |||| 00| 0 eng d | ||
| 022 | _a1523-3774 | ||
| 024 | _a10.1007/s11926-024-01147-8 [pii] | ||
| 040 | _aOvid MEDLINE(R) | ||
| 099 | _a38568326 | ||
| 245 | _aAA Amyloidosis: A Contemporary View. [Review] | ||
| 251 | _aCurrent Rheumatology Reports. 2024 Apr 03 | ||
| 252 | _aCurr Rheumatol Rep. 2024 Apr 03 | ||
| 253 | _aCurrent rheumatology reports | ||
| 260 | _c2024 | ||
| 260 | _p2024 Apr 03 | ||
| 265 | _saheadofprint | ||
| 265 | _tPublisher | ||
| 266 | _d2024-07-23 | ||
| 520 | _aPURPOSE OF REVIEW: Amyloid A (AA) amyloidosis is an organ- or life-threatening complication of chronic inflammatory disorders. Here, we review the epidemiology, causes, pathogenesis, clinical features, and diagnostic and therapeutic strategies of AA amyloidosis. | ||
| 520 | _aRECENT FINDINGS: The incidence of AA amyloidosis has declined due to better treatment of the underlying diseases. Histopathological examination is the gold standard of diagnosis, but magnetic resonance imaging can be used to detect cardiac involvement. There is yet no treatment option for the clearance of amyloid fibril deposits; therefore, the management strategy primarily aims to reduce serum amyloid A protein. Anti-inflammatory biologic agents have drastically expanded our therapeutic armamentarium. Kidney transplantation is preferred in patients with kidney failure, and the recurrence of amyloidosis in the allograft has become rare as transplant recipients have started to benefit from the new agents. The management of AA amyloidosis has been considerably changed over the recent years due to the novel therapeutic options aiming to control inflammatory activity. New agents capable of clearing amyloid deposits from the tissues are still needed. Copyright © 2024. The Author(s). | ||
| 546 | _aEnglish | ||
| 650 | _zAutomated | ||
| 650 | _aIN PROCESS -- NOT YET INDEXED | ||
| 656 | _aInternal Medicine Residency | ||
| 656 | _aMedStar Georgetown University Hospital/MedStar Washington Hospital Center | ||
| 657 | _aJournal Article | ||
| 657 | _aReview | ||
| 700 |
_aDoumas, Stavros _bMGUH _cInternal Medicine Residency _dMD |
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| 790 | _aMirioglu S, Uludag O, Hurdogan O, Kumru G, Berke I, Doumas SA, Frangou E, Gul A | ||
| 856 |
_uhttps://dx.doi.org/10.1007/s11926-024-01147-8 _zhttps://dx.doi.org/10.1007/s11926-024-01147-8 |
||
| 942 |
_cART _dArticle |
||
| 999 |
_c14194 _d14194 |
||