000			03603nam a22005177a 4500
008			130917s20122012 xxu||||| |||| 00| 0 eng dOvid Technologies
022			_a0002-9149
040			_aOvid MEDLINE(R)
099			_a22921999
245			_aMulti-ethnic study of atherosclerosis arterial age versus framingham 10-year or lifetime cardiovascular risk.
251			_aAmerican Journal of Cardiology. 110(11):1627-30, 2012 Dec 1.
252			_aAm J Cardiol. 110(11):1627-30, 2012 Dec 1.
253			_aThe American journal of cardiology
260			_c2012
260			_fFY2013
266			_d2013-09-17
501			_aAvailable online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
520			_aMethods to improve coronary heart disease (CHD) risk prediction include incorporation of coronary artery calcium (CAC) within risk models and considering longer time horizons such as evaluation of lifetime cardiovascular risk (LTR). We compared the accuracy of 10-year Framingham risk score (FRS), LTR, and Multi-Ethnic Study of Atherosclerosis (MESA) arterial age-adjusted 10-year risk for prediction of incident CHD events in men in the Prospective Army Coronary Calcium Project. We studied 1,633 healthy men (mean age 43 years, range 40 to 50 years, mean FRS 4.6%) with electron-beam computed tomography for CAC. Events (CHD death, myocardial infarction, acute coronary syndrome with nonelective coronary revascularization) were prospectively assessed over 5.6 +/- 1.5 years. Predicted risk using 10-year FRS for CHD and cardiovascular disease, LTR, and MESA arterial age were evaluated in relation with CAC and CHD events. CAC prevalence was strongly related to LTR, increasing in a graded fashion from 10.1% to 66.7% across 8 categories of increasing LTR. On receiver operating characteristic analysis, MESA arterial age (area under curve 0.78, 95% confidence interval 0.64 to 0.93) had the largest area under the curve but similar areas under the curve were observed for 10-year risk (CHD 0.74, 0.61 to 0.86; cardiovascular disease 0.70, 0.59 to 0.82), LTR (0.68, 0.49 to 0.76), and LTR with CAC as a covariate (0.76, 0.63 to 0.89). Inclusion of family history of CHD or body mass index did not improve model accuracy. In conclusion, increasing LTR was associated with increasingly prevalent CAC in this low-risk cohort and inclusion of CAC improved the accuracy of LTR for short-term event prediction. Published by Elsevier Inc.
546			_aEnglish
650			_a*Atherosclerosis/eh [Ethnology] _9911
650			_a*Coronary Artery Disease/eh [Ethnology] _9913
650			_a*Ethnic Groups _9886
650			_a*Risk Assessment/mt [Methods] _9916
650			_aAdult _913
650			_aAtherosclerosis/ra [Radiography] _9912
650			_aCoronary Artery Disease/ra [Radiography] _991
650			_aFollow-Up Studies _9914
650			_aForecasting _9915
650			_aHumans _911
650			_aMale _914
650			_aMiddle Aged _915
650			_aMilitary Personnel _9586
650			_aPrevalence _9605
650			_aProspective Studies _9177
650			_aRisk Factors _9311
650			_aROC Curve _9491
650			_aTomography, X-Ray Computed _9917
650			_aUnited States/ep [Epidemiology] _9251
651			_aMedStar Heart & Vascular Institute
657			_aComparative Study
657			_aJournal Article
700			_aTaylor, Allen J _9160
790			_aTaylor AJ, Villines TC
856			_uhttp://dx.doi.org/10.1016/j.amjcard.2012.07.018 _zhttp://dx.doi.org/10.1016/j.amjcard.2012.07.018
942			_cART _2z _dArticle
999			_c1424 _d1424