000			02763nam a22003617a 4500
008			240723s20242024 xxu||||| |||| 00| 0 eng d
022			_a2694-1902
024			_aCASE23765 [pii]
024			_aPMC10988234 [pmc]
040			_aOvid MEDLINE(R)
099			_a38560947
245			_aFirst use of intraventricular nicardipine in a pediatric patient with vasospasm secondary to meningitis: illustrative case.
251			_aJournal of Neurosurgery Case Lessons. 7(14), 2024 Apr 01.
252			_aJ. neurosurg., Case lessons. 7(14), 2024 Apr 01.
253			_aJournal of neurosurgery. Case lessons
260			_c2024
260			_p2024 Apr 01
260			_fFY2024
265			_sepublish
265			_tPubMed-not-MEDLINE
520			_aBACKGROUND: Cerebral vasospasm is commonly associated with adult aneurysmal subarachnoid hemorrhage but can develop in children. The standard vasospasm treatment includes induced hypertension, avoidance of hypovolemia, systemic use of the calcium channel blocker (CCB) nimodipine, and cerebral angiography for intraarterial therapy. Emerging treatments in adults, such as intraventricular CCB administration, have not been investigated in children. This study demonstrates the successful use of an intraventricular CCB in a pediatric patient with refractory vasospasm secondary to meningitis.
520			_aLESSONS: Pediatric vasospasm is uncommon and potentially devastating. The management of vasospasm in adults occurs frequently. Principles of this management are adapted to pediatric care given the rarity of vasospasm in children. The use of intraventricular nicardipine has been reported in the care of adults with level 3 evidence. It has not been adequately reported in children with refractory vasospasm. Here, the first use of intraventricular nicardipine in treating pediatric cerebral vasospasm in the setting of meningitis is described and highlighted.
520			_aOBSERVATIONS: A 12-year-old female presented with Streptococcus pneumoniae meningitis and ventriculitis with refractory symptomatic cerebral vasospasm. She received a 5-day course of intrathecal nicardipine through an existing external ventricular drain. Her clinical status, transcranial Doppler studies, and radiography improved. Treatment was well tolerated.
546			_aEnglish
650			_zAutomated
656			_aMedStar Georgetown University Hospital/MedStar Washington Hospital Center
656			_aNeurosurgery Residency
657			_aJournal Article
700			_aPatel, Nirali _bMGUH _cNeurosurgery Residency _dMD
790			_aHorak VJ, Patel N, Abdelmageed S, Scoville J, LoPresti MA, Lam S
856			_uhttps://dx.doi.org/10.3171/CASE23765 _zhttps://dx.doi.org/10.3171/CASE23765
942			_cART _dArticle
999			_c14249 _d14249