| 000 | 03142nam a22004337a 4500 | ||
|---|---|---|---|
| 008 | 240807s20242024 xxu||||| |||| 00| 0 eng d | ||
| 022 | _a0256-7040 | ||
| 024 | _a10.1007/s00381-024-06413-9 [pii] | ||
| 040 | _aOvid MEDLINE(R) | ||
| 099 | _a38702518 | ||
| 245 | _aThe role of focused ultrasound for pediatric brain tumors: current insights and future implications on treatment strategies. | ||
| 251 | _aChilds Nervous System. 2024 May 03 | ||
| 252 | _aChilds Nerv Syst. 2024 May 03 | ||
| 253 | _aChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery | ||
| 260 | _c2024 | ||
| 260 | _fFY2024 | ||
| 260 | _p2024 May 03 | ||
| 265 | _saheadofprint | ||
| 265 | _tPublisher | ||
| 266 | _d2024-08-07 | ||
| 266 | _z2024/05/03 23:29 | ||
| 520 | _aCONCLUSION: Discussions regarding future applications of FUS for the treatment of gliomas include improved drug delivery, immunomodulation, radiosensitization, and other technological advancements. Copyright © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | _aINTRODUCTION: Focused ultrasound (FUS) is an innovative and emerging technology for the treatment of adult and pediatric brain tumors and illustrates the intersection of various specialized fields, including neurosurgery, neuro-oncology, radiation oncology, and biomedical engineering. | ||
| 520 | _aMETHODS: The fundamental principles of FUS include its ability to induce thermal ablation or enhance drug delivery through transient blood-brain barrier (BBB) disruption, emphasizing the adaptability of high-intensity focused ultrasound (HIFU) and low-intensity focused ultrasound (LIFU) applications. | ||
| 520 | _aOBJECTIVE: The authors provide a comprehensive overview of the application and implications of FUS in treating pediatric brain tumors, with a special focus on pediatric low-grade gliomas (pLGGs) and the evolving landscape of this technology and its clinical utility. | ||
| 520 | _aRESULTS: Several ongoing clinical trials explore the potential of FUS in offering alternative therapeutic strategies for pathologies where conventional treatments fall short, specifically centrally-located benign CNS tumors and diffuse intrinsic pontine glioma (DIPG). A case illustration involving the use of HIFU for pilocytic astrocytoma is presented. | ||
| 546 | _aEnglish | ||
| 650 | _aIN PROCESS -- NOT YET INDEXED | ||
| 650 | _zAutomated | ||
| 656 | _aMedStar Georgetown University Hospital/MedStar Washington Hospital Center | ||
| 656 | _aNeurosurgery Residency | ||
| 657 | _aJournal Article | ||
| 700 |
_aChesney, Kelsi _bMGUH _cNeurosurgery Residency _dMD |
||
| 700 |
_aKeating, Gregory _bMGUH _cNeurosurgery Residency _dMD |
||
| 700 |
_aPatel, Nirali _bMGUH _cNeurosurgery Residency _dMD |
||
| 790 | _aChesney KM, Keating GF, Patel N, Kilburn L, Fonseca A, Wu CC, Nazarian J, Packer RJ, Donoho DA, Oluigbo C, Myseros JS, Keating RF, Syed HR | ||
| 856 |
_uhttps://dx.doi.org/10.1007/s00381-024-06413-9 _zhttps://dx.doi.org/10.1007/s00381-024-06413-9 |
||
| 942 |
_cART _dArticle |
||
| 999 |
_c14441 _d14441 |
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