000 02656nam a22004337a 4500
008 240807s20242024 xxu||||| |||| 00| 0 eng d
022 _a2328-8957
024 _aofae286 [pii]
024 _aPMC11167671 [pmc]
040 _aOvid MEDLINE(R)
099 _a38868314
245 _aFungal Foe and Mechanical Hearts: A Retrospective Case Series on Candida auris Bloodstream Infection With Left Ventricular Assist Devices.
251 _aOpen Forum Infectious Diseases. 11(6):ofae286, 2024 Jun.
252 _aOpen forum infect. dis.. 11(6):ofae286, 2024 Jun.
253 _aOpen forum infectious diseases
260 _c2024
260 _fFY2024
260 _p2024 Jun
265 _sepublish
265 _tPubMed-not-MEDLINE
266 _d2024-08-07
266 _z2024/06/13 04:30
520 _aNo guidelines currently exist for the management of Candida auris bloodstream infection in patients with left ventricular assist devices (LVADs). We aim to share our management experience through this retrospective case series outlining 15 episodes of C auris candidemia identified in 7 patients over 18 months. The initial source of candidemia was central venous catheter in 5 patients, driveline exit site infection in 1 patient, and possible pump infection in 1 patient. All patients were initially treated with micafungin. Despite susceptibility to micafungin, 4 patients experienced recurrent C auris candidemia. All patients died within 1 year of their first episode of C auris candidemia. Source control is challenging in patients with LVADs, and strict infection prevention measures should be practiced. More studies are needed to evaluate the role of newer antifungal agents, use of combination antifungal regimens, and impact on morbidity in patients with LVADs. Copyright © The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
546 _aEnglish
650 _zAutomated
651 _aMedStar Washington Hospital Center
656 _aDepartment of Internal Medicine/Infectious Disease
656 _aInternal Medicine Residency
656 _aPhysical Medicine and Rehabilitation
657 _aCase Reports
657 _aJournal Article
700 _aDoshi, Saumil
_bMWHC
700 _aKerai, Ajay
_bMWHC
_cInternal Medicine Residency
_dMD
700 _aLaleker, Ashley
_bMWHC
790 _aKerai A, Doshi S, Laleker A, Majumdar A
856 _uhttps://dx.doi.org/10.1093/ofid/ofae286
_zhttps://dx.doi.org/10.1093/ofid/ofae286
858 _yKerai, Ajay
_uhttps://orcid.org/0009-0002-3818-4012
_zhttps://orcid.org/0009-0002-3818-4012
942 _cART
_dArticle
999 _c14481
_d14481