000			04267nam a22007097a 4500
008			240807s20242024 xxu||||| |||| 00| 0 eng d
022			_a0160-9289
024			_aPMC11151004 [pmc]
040			_aOvid MEDLINE(R)
099			_a38838029
245			_aPREDICT HF: Risk stratification in advanced heart failure using novel hemodynamic parameters.
251			_aClinical Cardiology. 47(6):e24277, 2024 Jun.
252			_aClin Cardiol. 47(6):e24277, 2024 Jun.
253			_aClinical cardiology
260			_c2024
260			_fFY2024
260			_p2024 Jun
265			_sppublish
265			_tMEDLINE
266			_d2024-08-07
266			_z2024/06/05 13:43
501			_aAvailable online from MWHC library: 1976 - present, Available in print through MWHC library:1999-2007
520			_aBACKGROUND: Invasive hemodynamics are fundamental in assessing patients with advanced heart failure (HF). Several novel hemodynamic parameters have been studied; however, the relative prognostic potential remains ill-defined.
520			_aCONCLUSION: The advanced hemodynamic parameters API and CPO are independently associated with death or the need for OHT or LVAD within 6 months. Further prospective studies are needed to validate these parameters and elucidate their role in patients with advanced HF. Copyright © 2024 The Authors. Clinical Cardiology published by Wiley Periodicals, LLC.
520			_aHYPOTHESIS: Advanced hemodynamic parameters provide additional prognostication beyond the standard hemodynamic assessment.
520			_aMETHODS: Patients from the PRognostic Evaluation During Invasive CaTheterization for Heart Failure (PREDICT-HF) registry who underwent right heart catheterization (RHC) were included in the analysis. The primary endpoint was survival to orthotopic heart transplant (OHT) or durable left ventricular assist device (LVAD), or death within 6 months of RHC.
520			_aRESULTS: Of 846 patients included, 176 (21%) met the primary endpoint. In a multivariate model that included traditional hemodynamic variables, pulmonary capillary wedge pressure (PCWP) (OR: 1.10, 1.04-1.15, p < .001), and cardiac index (CI) (OR: 0.86, 0.81-0.92, p < .001) were shown to be predictive of adverse outcomes. In a separate multivariate model that incorporated advanced hemodynamic parameters, cardiac power output (CPO) (OR: 0.76, 0.71-0.83, p < .001), aortic pulsatility index (API) (OR: 0.94, 0.91-0.96, p < .001), and pulmonary artery pulsatility index (OR: 1.02, 1.00-1.03, p .027) were all significantly associated with the primary outcome. Positively concordant API and CPO afforded the best freedom from the endpoint (94.7%), whilst negatively concordant API and CPO had the worst freedom from the endpoint (61.5%, p < .001). Those with discordant API and CPO had similar freedom from the endpoint.
546			_aEnglish
650			_a*Cardiac Catheterization
650			_a*Heart Failure
650			_a*Hemodynamics
650			_a*Registries
650			_aAged
650			_aFemale
650			_aHeart Failure/di [Diagnosis]
650			_aHeart Failure/mo [Mortality]
650			_aHeart Failure/pp [Physiopathology]
650			_aHeart Failure/th [Therapy]
650			_aHeart Transplantation
650			_aHeart-Assist Devices
650			_aHemodynamics/ph [Physiology]
650			_aHumans
650			_aMale
650			_aMiddle Aged
650			_aPredictive Value of Tests
650			_aPrognosis
650			_aPulmonary Wedge Pressure/ph [Physiology]
650			_aRetrospective Studies
650			_aRisk Assessment/mt [Methods]
650			_aRisk Factors
650			_aTime Factors
650			_aUnited States/ep [Epidemiology]
650			_aVentricular Function, Left/ph [Physiology]
650			_zCurated
651			_aMedStar Heart & Vascular Institute
657			_aJournal Article
657			_aMulticenter Study
700			_aNajjar, Samer S _bMHVI
790			_aCyrille-Superville N, Rao SD, Feliberti JP, Patel PA, Swayampakala K, Sinha SS, Jeng EI, Goswami RM, Snipelisky DF, Carroll AM, Najjar SS, Belkin M, Grinstein J
856			_uhttps://dx.doi.org/10.1002/clc.24277 _zhttps://dx.doi.org/10.1002/clc.24277
942			_cART _dArticle
999			_c14530 _d14530