000			03947nam a22005297a 4500
008			240807s20242024 xxu||||| |||| 00| 0 eng d
022			_a0196-8092
040			_aOvid MEDLINE(R)
099			_a38769894
245			_aEfficacy of laser hair removal in hidradenitis suppurativa: A systematic review and meta-analysis. [Review]
251			_aLasers in Surgery & Medicine. 56(5):425-436, 2024 07.
252			_aLasers Surg Med. 56(5):425-436, 2024 07.
253			_aLasers in surgery and medicine
260			_c2024
260			_fFY2024
260			_p2024 07
265			_sppublish
265			_tMEDLINE
266			_d2024-08-07
266			_z2024/05/21 03:04
520			_aCONCLUSIONS: Hair follicles are key in HS pathogenesis and all included studies showed a significant improvement in HS disease severity after LHR regardless of the laser device used, likely related to hair follicle unit destruction. HS is a complex and heterogenous condition, and multiple disease scoring methods complicate outcome comparisons across studies. However, LHR, utilizing various techniques, is an effective treatment option for HS with minimal adverse effects. Copyright © 2024 Wiley Periodicals LLC.
520			_aMETHODS: A comprehensive literature search was conducted from inception to September 2023 in Ovid MEDLINE, Ovid Embase, and The Cochrane Library (Wiley) with predefined inclusion and exclusion criteria, and a meta-analysis was conducted.
520			_aOBJECTIVES: Hidradenitis suppurativa (HS) is a chronic inflammatory condition characterized by painful nodules, draining tunnels, and fibrotic scarring in intertriginous, hair-bearing areas. The pathogenesis involves follicular occlusion and subsequent rupture, leading to uncontrolled inflammation. Treatment options for HS are limited and lack universal effectiveness. Laser hair removal (LHR) has been explored as a potential treatment; however, the efficacy and appropriate laser modalities remain unclear. This systematic review examined the efficacy and adverse effects of LHR in HS.
520			_aRESULTS: Ten studies were selected (n = 227 total patients) and included six randomized controlled trials, two nonrandomized experimental studies, and two case series. Various laser modalities, including long-pulsed neodymium-doped yttrium aluminum garnet (Nd:YAG) (n = 115), intense pulsed light (n = 18), Alexandrite (n = 54), intralesional 1064 nm diode (n = 20), and combined fractional CO2 and long-pulsed Nd:YAG laser (n = 20), consistently demonstrated significant improvement in HS disease severity, irrespective of the disease scoring method used. Minimal adverse effects (primarily mild pain and erythema) were reported. A meta-analysis of three studies utilizing long-pulsed Nd:YAG laser demonstrated a standardized mean difference in disease severity of -1.68 (95% confidence interval: -2.99; -0.37), favoring treatment with LHR for HS.
546			_aEnglish
650			_a*Hair Removal
650			_a*Hidradenitis Suppurativa
650			_aHair Removal/mt [Methods]
650			_aHidradenitis Suppurativa/su [Surgery]
650			_aHidradenitis Suppurativa/th [Therapy]
650			_aHumans
650			_aLaser Therapy/mt [Methods]
650			_aLasers, Solid-State/tu [Therapeutic Use]
650			_aTreatment Outcome
650			_zCurated
651			_aMedStar Washington Hospital Center
656			_aDermatology Residency N
657			_aJournal Article
657			_aMeta-Analysis
657			_aReview
657			_aSystematic Review
700			_aWilliams, Monica _bMWHC _cDermatology Residency _dMD
790			_aShipman WD 3rd, Williams MN, Suozzi KC, Eisenstein AS, Dover JS
856			_uhttps://dx.doi.org/10.1002/lsm.23796 _zhttps://dx.doi.org/10.1002/lsm.23796
858			_yShipman, William D 3rd _uhttps://orcid.org/0000-0002-7911-0610 _zhttps://orcid.org/0000-0002-7911-0610
942			_cART _dArticle
999			_c14560 _d14560