000			02912nam a22003977a 4500
008			160715s20152015 xxu||||| |||| 00| 0 eng d
022			_a2213-1779
040			_aOvid MEDLINE(R)
099			_a26362444
245			_a"Targeting the Heart" in Heart Failure: Myocardial Recovery in Heart Failure With Reduced Ejection Fraction. [Review]
251			_aJACC Heart Failure. 3(9):661-9, 2015 Sep.
252			_aJACC Heart Fail. 3(9):661-9, 2015 Sep.
253			_aJACC. Heart failure
260			_c2015
260			_fFY2016
266			_d2016-07-15
520			_aMyocardial recovery in heart failure (HF) is possible, but its determinants are not fully defined. At least partial functional improvement is possible with current evidence-based therapies. However, once significant HF symptoms develop, patients have varied trajectories, including: 1) structural and functional recovery; 2) stabilization (remission); and 3) acceleration to end-stage HF/death. All 3 trajectories may be interrupted by sudden death. These trajectories may represent the interplay of heterogeneous causality, genetic predeterminants, and disease phenotypes. Enhanced phenotypic description with cardiac magnetic resonance imaging, molecular imaging, or circulating biomarkers of the heterogeneous HF population may provide insights regarding specific biological targets amenable to existing and novel therapeutic strategies. The identification of patients in "remission," before progression to the end stage of predominantly nonviable tissue (e.g., fibrosis), has implications for clinical practice and future trials because such patients may be more likely to experience myocardial recovery (cardiac reserve). The identification of dysfunctional but viable myocardium and its diverse pathophysiological causes may provide opportunities to investigate existing and novel therapeutics aimed at enhancing myocardial recovery.Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
546			_aEnglish
650			_a*Heart Failure/pp [Physiopathology]
650			_a*Myocardial Contraction/ph [Physiology]
650			_a*Recovery of Function
650			_a*Stroke Volume/ph [Physiology]
650			_a*Ventricular Function, Left/ph [Physiology]
650			_aHeart Failure/di [Diagnosis]
650			_aHumans
650			_aMagnetic Resonance Imaging, Cine
650			_aMyocardium/pa [Pathology]
651			_aMedStar Health Research Institute
657			_aJournal Article
657			_aResearch Support, Non-U.S. Gov't
657			_aReview
700			_aEpstein, Stephen E
790			_aArdehali H, Bonow RO, Butler J, Diez J, Epstein SE, Fonarow GC, Gheorghiade M, Khan SS, Kim RJ, Sabbah HN, Sauer AJ, Wilcox JE
856			_uhttp://dx.doi.org/10.1016/j.jchf.2015.04.011 _zhttp://dx.doi.org/10.1016/j.jchf.2015.04.011
942			_cART _dArticle
999			_c1812 _d1812