000			03902nam a22005777a 4500
008			170428s20172017 xxu||||| |||| 00| 0 eng d
022			_a2047-2404
040			_aOvid MEDLINE(R)
099			_a28200140
245			_aSerial volumetric assessment of coronary fibroatheroma by optical frequency domain imaging: insights from the TROFI trial.
251			_aEuropean heart journal cardiovascular Imaging. 19(1):92-100, 2018 01 01.
252			_aEur Heart J Cardiovasc Imaging. 19(1):92-100, 2018 01 01.
253			_aEuropean heart journal cardiovascular Imaging
260			_c2017
260			_fFY2017
265			_sppublish
266			_d2017-05-06
520			_aAims: Coronary lesions precursors of acute events remain elusive, since they undergo continuous changes and their temporal changes are not very well-characterized. In natural history studies, optical frequency domain imaging (OFDI) has been used only to assess fibroatheromas as a 2D structure and sometimes in a single frame fashion. We aim at describing the serial volumetric modifications of the fibrous cap (FC) of the fibroatheromas as determined by OFDI over a 6-month follow-up period.
520			_aConclusions: Non-culprit fibroatheromas located in the infarct related artery of patients with STEMI had a volumetric reduction of the FC after 6-month follow-up. Quantitative FC assessment was able to differentiate high-risk lesions that became ThCFAs. There was a considerable change of plaque phenotype (TCFAs or ThCFAs) over time.
520			_aCopyright Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: [email protected].
520			_aMethods and results: In 49 patients, OFDI investigation was performed following treatment of culprit lesion and at 6-month follow-up in patients with ST-segment elevation myocardial infarction (STEMI). A fully automatic volumetric quantification of FC was done in all lipid-containing frames of non-culprit lesions in the infarct related artery. These lesions were matched at baseline and 6-month follow-up. A total of 58 non-culprit lipid rich lesions (34 TCFAs and 24 thick-cap fibroatheroma [ThCFA]) were found in 34 patients at baseline. Overall, there was a FC volume decrease of 1.57 (Inter-quartile Range [IQR] -4.13 to 0.54) mm3 at 6-months. 27% of the lesions changed their phenotype over time (TCFA or ThCFA). TCFAs that became ThCFAs at follow-up had smaller mean and maximal FC as compared with lesions that remained TCFAs (P = 0.01 for both).
546			_aEnglish
650			_a*Coronary Artery Disease/dg [Diagnostic Imaging]
650			_a*Plaque, Atherosclerotic/dg [Diagnostic Imaging]
650			_a*ST Elevation Myocardial Infarction/th [Therapy]
650			_a*Thrombectomy/mt [Methods]
650			_a*Tomography, Optical Coherence/mt [Methods]
650			_aAged
650			_aCombined Modality Therapy
650			_aCoronary Artery Disease/th [Therapy]
650			_aFemale
650			_aFollow-Up Studies
650			_aHumans
650			_aMale
650			_aMiddle Aged
650			_aPercutaneous Coronary Intervention
650			_aPlaque, Atherosclerotic/su [Surgery]
650			_aProspective Studies
650			_aRisk Assessment
650			_aST Elevation Myocardial Infarction/dg [Diagnostic Imaging]
650			_aST Elevation Myocardial Infarction/mo [Mortality]
650			_aSurvival Rate
650			_aTime Factors
650			_aTreatment Outcome
651			_aMedStar Heart & Vascular Institute
657			_aJournal Article
700			_aGarcia-Garcia, Hector M
790			_aCampos CM, Dijkstra J, Garcia-Garcia HM, Iqbal J, Muramatsu T, Nakatani S, Onuma Y, Serruys PW
856			_uhttps://dx.doi.org/10.1093/ehjci/jew338 _zhttps://dx.doi.org/10.1093/ehjci/jew338
942			_cART _dArticle
999			_c2139 _d2139