000			03742nam a22005537a 4500
008			170602s20172017 xxu||||| |||| 00| 0 eng d
022			_a0002-9149
040			_aOvid MEDLINE(R)
099			_a28159195
245			_aInfluence of Left Ventricular Stroke Volume on Incident Heart Failure in a Population With Preserved Ejection Fraction (from the Strong Heart Study).
251			_aAmerican Journal of Cardiology. 119(7):1047-1052, 2017 Apr 01
252			_aAm J Cardiol. 119(7):1047-1052, 2017 Apr 01
253			_aThe American journal of cardiology
260			_c2017
260			_f2017
266			_d2017-06-13
501			_aAvailable online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
520			_aAt a given level of left ventricular (LV) systolic function, LV pump performance (assessed by stroke index [SVi]) may differ, depending on LV size. We evaluated whether low SVi may be considered a marker of risk for incident congestive heart failure (HF), independent of LV geometry and systolic function, assessed by ejection fraction (EF) or midwall fractional shortening (MFS), in a large population-based sample with normal EF. Clinical and echocardiographic data from the second Strong Heart Study (SHS) examination, including 2,885 American Indians (59 +/- 8 years; 63% women) with normal EF (EF >=51% in men and EF >=55% in women) and without prevalent HF or significant valve disease, were analyzed. Low SVi was defined as SVi <=22 ml/m<sup>2.04</sup>. Low SVi was more common among men and associated with lower body mass index, systolic blood pressure, LV mass index, left atrial dimension, EF, and MFS and with higher relative wall thickness. During a mean 12-year follow-up, 209 participants developed HF and 246 had acute myocardial infarction. In Cox regression analysis, low SVi was associated with higher risk of incident HF (hazard ratio 1.38; 95% confidence interval 1.06 to 1.80), independently of age, gender, body mass index, heart rate, hypertension, prevalent cardiovascular disease, left atrial dimension index, LV mass index, LV concentric geometry, EF or MFS, and abnormal wall motion, also accounting for myocardial infarction as a competing risk event. In conclusion, in the SHS, low SVi was associated with higher incident rate of HF, independently of LV geometry and systolic function and other major confounders.
520			_aCopyright © 2017 Elsevier Inc. All rights reserved.
546			_aEnglish
650			_a*Heart Failure/pp [Physiopathology]
650			_a*Indians, North American
650			_a*Ventricular Dysfunction, Left/pp [Physiopathology]
650			_aAged
650			_aDiabetes Mellitus/ep [Epidemiology]
650			_aDiagnostic Imaging
650			_aFemale
650			_aHeart Failure/di [Diagnosis]
650			_aHeart Failure/ep [Epidemiology]
650			_aHumans
650			_aHypertension/ep [Epidemiology]
650			_aIncidence
650			_aMale
650			_aMiddle Aged
650			_aObesity/ep [Epidemiology]
650			_aPrevalence
650			_aRisk Factors
650			_aSex Factors
650			_aStroke Volume/ph [Physiology]
650			_aUnited States/ep [Epidemiology]
650			_aVentricular Dysfunction, Left/di [Diagnosis]
650			_aVentricular Dysfunction, Left/ep [Epidemiology]
651			_aMedStar Health Research Institute
657			_aJournal Article
700			_aHoward, Barbara V
790			_aDe Marco M, de Simone G, Devereux RB, Gerdts E, Howard BV, Lee ET, Lonnebakken MT, Mancusi C, Roman MJ
856			_uhttps://dx.doi.org/10.1016/j.amjcard.2016.12.011 _zhttps://dx.doi.org/10.1016/j.amjcard.2016.12.011
942			_cART _dArticle
999			_c2389 _d2389