000			03560nam a22004817a 4500
008			221018s20222022 xxu||||| |||| 00| 0 eng d
022			_a1878-0938
024			_a10.1016/j.carrev.2022.08.008 [doi]
024			_aS1553-8389(22)00704-7 [pii]
040			_aOvid MEDLINE(R)
099			_a36058829
245			_aAdditive effect of multiple high-risk coronary artery segments on patient outcomes: LRP Study sub-analysis.
251			_aCardiovascular Revascularization Medicine. 2022 Aug 06
252			_aCardiovasc Revasc Med. 2022 Aug 06
253			_aCardiovascular revascularization medicine : including molecular interventions
260			_c2022
260			_fFY2023
260			_p2022 Aug 06
265			_saheadofprint
266			_d2022-10-20
520			_aBACKGROUND: The Lipid Rich Plaque (LRP) Study established the association between high volume of lipidic content (maximum Lipid Core Burden Index [maxLCBI4mm] >400) in the coronary arteries and subsequent non-culprit major adverse cardiac events (NC-MACE). This analysis sought to assess the clinical impact of more than one lipid-rich plaque in the coronary tree.
520			_aCLINICAL TRIAL REGISTRATION: The Lipid-Rich Plaque Study (LRP), https://clinicaltrials.gov/ct2/show/NCT02033694, NCT02033694. Copyright © 2022 Elsevier Inc. All rights reserved.
520			_aCONCLUSION: There is a stepwise increased risk of all-cause death, cardiac death, any revascularization, and NC-MACE according to the number of coronary segments with maxLCBI4mm > 400. In contrast, maxLCBI4mm = 0 results in a low event rate.
520			_aMETHODS: The LRP patient population was divided into four cohorts: 1) patients with all segments with maxLCBI4mm = 0; 2) patients with all coronary segments maxLCBI4mm < 400, but >0; 3) patients with 1 segment maxLCBI4mm > 400; and 4) patients with 2+ coronary segments with maxLCBI4mm > 400. Baseline characteristics, plaque-level characteristics, and follow-up outcomes were described.
520			_aRESULTS: Among 1550 patients, only 3.2 % had all segments with maxLCBI4mm = 0; 65.1 % had segments with maxLCBI4mm > 0 but <400; 22.5 % had one segment with maxLCBI4mm > 400; and 9.5 % had 2+ coronary segments with maxLCBI4mm > 400. Distribution within the coronary tree (one versus multiple arteries) did not differ. Overall, 1269 patients were allocated to follow-up (per study design). The composite of all-cause death, cardiac death, any revascularization, and NC-MACE was statistically higher in patients with 1 segment maxLCBI4mm > 400 and numerically even higher in patients with 2+ segments with maxLCBI4mm > 400. Patients with maxLCBI4mm = 0 had no events within two years.
546			_aEnglish
650			_aIN PROCESS -- NOT YET INDEXED
651			_aMedStar Heart & Vascular Institute
651			_aMedStar Washington Hospital Center
656			_aInterventional Cardiology Fellowship
657			_aJournal Article
700			_aCase, Brian C _bMHVI
700			_aDi Mario, Carlo _bMHVI
700			_aGarcia-Garcia, Hector M _bMHVI
700			_aMedranda, Giorgio _bMWHC _cInterventional Cardiology Fellowship _dMD _eAlumni
700			_aMintz, Gary S _bMHVI
700			_aShea, Corey _bMHVI
700			_aWaksman, Ron _bMHVI
700			_aZhang, Cheng _bMHVI
790			_aCase BC, Di Mario C, Garcia-Garcia HM, Medranda GA, Mintz GS, Shea C, Torguson R, Waksman R, Zhang C
856			_uhttps://dx.doi.org/10.1016/j.carrev.2022.08.008 _zhttps://dx.doi.org/10.1016/j.carrev.2022.08.008
942			_cART _dArticle
999			_c251 _d251