000			03499nam a22005777a 4500
008			181214s20182018 xxu||||| |||| 00| 0 eng d
022			_a0025-7974
024			_a00005792-201811160-00002 [pii]
024			_a10.1097/MD.0000000000012614 [doi]
040			_aOvid MEDLINE(R)
099			_a30431560
245			_aBrief topical sodium nitrite and its impact on the quality of life in patients with sickle leg ulcers.
251			_aMedicine. 97(46):e12614, 2018 Nov.
252			_aMedicine (Baltimore). 97(46):e12614, 2018 Nov.
253			_aMedicine
260			_c2018
260			_fFY2019
265			_sppublish
266			_d2018-12-14
501			_aAvailable online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
520			_aCutaneous ulceration from sickle cell disease negatively impacts quality of life. Topical sodium nitrite has previously been shown to reduce the size of sickle leg ulcers. This study examined how topical sodium nitrite impacted the quality of life scores in patients with sickle leg ulcers.We prospectively collected data in patients enrolled in a leg ulcer study (n = 17) or an allogeneic hematopoietic cell transplant study (nonulcer group, n = 15). Both groups completed a pretreatment Short Form-36 questionnaire; the ulcer group completed a second questionnaire after 4 weeks of topical sodium nitrite applications. Data were analyzed by age, sex, >50% area improvement postintervention, and sickle-related complications (vaso-occlusive crises, pulmonary hypertension, or avascular necrosis). Physical and mental component summary scores were analyzed with Student t test.Physical summary scores were lower than mental summary scores in all groups, indicating leg ulcers among other sickle related complications negatively impacted physical quality of life measures. After sodium nitrite use, physical summary scores improved in the leg ulcer group (34.5 +/- 9.4 to 39 +/- 10.3, P = .03), and mental summary scores improved more in ulcerated patients <=35 years old (40.7 +/- 6.9 to 51.7 +/- 9.7, P = .01).Brief topical sodium nitrite has the potential to improve quality of life, especially in younger individuals. Longer treatment duration and randomized-controlled trials are needed to confirm the efficacy of this topical therapy.
546			_aEnglish
650			_a*Anemia, Sickle Cell/co [Complications]
650			_a*Leg Ulcer/dt [Drug Therapy]
650			_a*Patient Reported Outcome Measures
650			_a*Quality of Life
650			_a*Sodium Nitrite/ad [Administration & Dosage]
650			_aAdministration, Topical
650			_aAdolescent
650			_aAdult
650			_aFemale
650			_aHematopoietic Stem Cell Transplantation
650			_aHumans
650			_aIN PROCESS -- NOT YET INDEXED
650			_aLeg Ulcer/et [Etiology]
650			_aMale
650			_aMiddle Aged
650			_aPreoperative Period
650			_aProspective Studies
650			_aTreatment Outcome
650			_aWound Healing/de [Drug Effects]
650			_aYoung Adult
651			_aMedStar National Rehabilitation Network
657			_aClinical Trial
657			_aJournal Article
700			_aConnor, Joseph L Jr
700			_aSclafani, Joseph A
790			_aConnor JL Jr, Hsieh MM, Kato GJ, Minniti CP, Sclafani JA
856			_uhttps://dx.doi.org/10.1097/MD.0000000000012614 _zhttps://dx.doi.org/10.1097/MD.0000000000012614
942			_cART _dArticle
999			_c3953 _d3953