000			02744nam a22004577a 4500
008			191219s20202020 xxu||||| |||| 00| 0 eng d
022			_a1121-8428
024			_a10.1007/s40620-019-00680-5 [doi]
024			_a10.1007/s40620-019-00680-5 [pii]
040			_aOvid MEDLINE(R)
099			_a31782127
245			_aRed cell transfusion in chronic kidney disease in the United States in the current era of erythropoiesis stimulating agents. [Review]
251			_aJournal of Nephrology. 33(2):267-275, 2020 Apr.
252			_aJ Nephrol. 33(2):267-275, 2020 Apr.
252			_zJ Nephrol. 2019 Nov 28
253			_aJournal of nephrology
260			_c2020
260			_fFY2020
265			_saheadofprint
265			_sppublish
266			_d2019-12-17
268			_aJournal of Nephrology. 2019 Nov 28
520			_aAnemia is a major complication of chronic kidney disease (CKD) that leads to many symptoms of this disease and worsens cardiovascular health. Treatment of this condition was revolutionized three decades ago by the commercial availability of recombinant human erythropoietin which held the promise of completely eliminating the need for red blood cell transfusion (RBCT). Despite specific therapy now available for anemia in CKD, clinical data accumulated in the last 2 decades suggests that there is a continued need for RBCT, which, we surmise, is due to underutilization of Erythropoietin Stimulating Agents (ESA) or clinical settings such as active bleed, bone marrow resistance such as myelofibrosis or infections where ESAs are ineffective. The purpose of this narrative review is to highlight the adverse effects and summarize the current patterns of RBCT use in all stages of CKD while elaborating on the clinical characteristics of patients that increases their risks of transfusion exposure. We discuss, briefly, salient features of the pathophysiology of anemia in CKD and its contemporary therapies while presenting our perspectives on how to optimize transfusion strategies without compromising patient safety.
546			_aEnglish
650			_a*Erythrocyte Transfusion
650			_a*Hematinics/tu [Therapeutic Use]
650			_a*Renal Dialysis
650			_a*Renal Insufficiency, Chronic/th [Therapy]
650			_aHumans
650			_aUnited States
651			_aMedStar Washington Hospital Center
656			_aMedicine/Nephrology
657			_aJournal Article
657			_aReview
700			_aAhsan, Muhammad
700			_aBrenner, Nicole
700			_aGanguli, Anirban
790			_aAhsan M, Brenner N, Ganguli A, Kommalapati A
856			_uhttps://dx.doi.org/10.1007/s40620-019-00680-5 _zhttps://dx.doi.org/10.1007/s40620-019-00680-5
942			_cART _dArticle
999			_c4807 _d4807