000			03249nam a22005057a 4500
008			200210s20202020 xxu||||| |||| 00| 0 eng d
022			_a1071-9164
024			_a10.1016/j.cardfail.2020.01.012 [doi]
024			_aS1071-9164(19)31407-1 [pii]
040			_aOvid MEDLINE(R)
099			_a31981696
245			_aHVAD Flow Waveform Estimates Left Ventricular Filling Pressure.
251			_aJournal of Cardiac Failure. 26(4):342-348, 2020 Apr.
252			_aJ Card Fail. 26(4):342-348, 2020 Apr.
252			_zJ Card Fail. 2020 Jan 22
253			_aJournal of cardiac failure
260			_c2020
260			_fFY2020
265			_saheadofprint
265			_sppublish
266			_d2020-02-10
268			_aJournal of Cardiac Failure. 2020 Jan 22
501			_aAvailable online from MWHC library: 1995 - present
520			_aBACKGROUND: HVAD left ventricular assist device (LVAD) flow waveforms provides graphical real-time information linking device performance with invasive hemodynamics. Previous studies have demonstrated a good correlation between the slopes of the ventricular filling phase (VFPS) and directly measured pulmonary capillary wedge pressure (PCWP). We aimed to validate the utility of VFPS to estimate PCWP and predict clinical outcomes.
520			_aCONCLUSIONS: VFPS of the HVAD flow waveform is a novel noninvasive parameter that can estimate PCWP. Copyright (c) 2020 Elsevier Inc. All rights reserved.
520			_aMETHODS: In this prospective blinded study, screenshots from the HVAD monitor and simultaneous invasive hemodynamic measurements were obtained. Each screenshot was digitized and the VFPS was calculated by two independent readers who were blinded to the hemodynamic results. The equation PCWP=7.053 +1.365x(VFPS) was derived from a previously published data set and the estimated PCWP was correlated to the actually measured PCWP.
520			_aRESULTS: 131 sets of simultaneous measurements (VFPS and PCWP) were obtained from 27 HVAD patients (mean age 55 years, 47% male). A previously proposed cutoff of VFPS >=5.8 L/min/sec predicted PCWP >=18 mmHg with 91.5% sensitivity and 95.2% specificity with the area under curve of 0.987. The estimated PCWP significantly correlated with measured PCWP (R2=0.65, p <0.001) and showed acceptable agreement with measured PCWP. Patients with VFPS >=5.8 L/min/sec experienced significantly higher heart failure readmission rates than those without (0.24 vs. 0.05 events/year, p <0.001).
546			_aEnglish
650			_a*Heart Failure
650			_a*Heart-Assist Devices
650			_aFemale
650			_aHeart Failure/di [Diagnosis]
650			_aHeart Ventricles/dg [Diagnostic Imaging]
650			_aHumans
650			_aMale
650			_aMiddle Aged
650			_aProspective Studies
650			_aPulmonary Wedge Pressure
651			_aMedStar Heart & Vascular Institute
657			_aJournal Article
700			_aGrinstein, Jonathan
790			_aFujino T, Grinstein J, Imamura T, Jeevanandam V, Kim G, Narang N, Nguyen A, Nitta D, Rodgers D, Sayer G, Uriel N
856			_uhttps://dx.doi.org/10.1016/j.cardfail.2020.01.012 _zhttps://dx.doi.org/10.1016/j.cardfail.2020.01.012
942			_cART _dArticle
999			_c4918 _d4918