| 000 | 01970nam a22003497a 4500 | ||
|---|---|---|---|
| 008 | 200709s20202020 xxu||||| |||| 00| 0 eng d | ||
| 022 | _a2072-1439 | ||
| 024 | _a10.21037/jtd.2019.11.48 [doi] | ||
| 024 | _ajtd-12-S1-S48 [pii] | ||
| 024 | _aPMC7024759 [pmc] | ||
| 040 | _aOvid MEDLINE(R) | ||
| 099 | _a32148925 | ||
| 245 | _aThe origins of the Lacto-Bolo reflex: the mythology of lactate in sepsis. [Review] | ||
| 251 | _aJournal of Thoracic Disease. 12(Suppl 1):S48-S53, 2020 Feb. | ||
| 252 | _aJ. thorac. dis.. 12(Suppl 1):S48-S53, 2020 Feb. | ||
| 253 | _aJournal of thoracic disease | ||
| 260 | _c2020 | ||
| 260 | _fFY2020 | ||
| 265 | _sppublish | ||
| 266 | _d2020-07-09 | ||
| 520 | _aThe use of lactate as a marker of the severity of circulatory shock was popularized by Dr. Weil in the 1970's. Dr. Weil promoted the idea that blood lactate concentration increased in circulatory shock due to anaerobic metabolism following decreased oxygen delivery. This concept becomes entrenched with 1992 ACCP/SCCM consensus conference definition of sepsis. Since then, the central role of lactate in the definition and management of septic shock has only been expanded and become more ingrained. This review will discuss the wisdom of such an approach, an updated model describing the origins of hyperlactatemia in sepsis, and how such improvements in our knowledge of the underlying physiology should change our approach to resuscitation in patients presenting with septic shock. Copyright 2020 Journal of Thoracic Disease. All rights reserved. | ||
| 546 | _aEnglish | ||
| 650 | _aIN PROCESS -- NOT YET INDEXED | ||
| 651 | _aMedStar Washington Hospital Center | ||
| 656 | _aEmergency Medicine | ||
| 657 | _aJournal Article | ||
| 657 | _aReview | ||
| 700 | _aSpiegel, Rory | ||
| 790 | _aGordon D, Marik PE, Spiegel R | ||
| 856 |
_uhttps://dx.doi.org/10.21037/jtd.2019.11.48 _zhttps://dx.doi.org/10.21037/jtd.2019.11.48 |
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| 942 |
_cART _dArticle |
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| 999 |
_c5237 _d5237 |
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