000			02904nam a22003137a 4500
008			210310s20212021 xxu||||| |||| 00| 0 eng d
022			_a2509-2723
024			_a10.1007/s11357-020-00321-x [doi]
024			_a10.1007/s11357-020-00321-x [pii]
040			_aOvid MEDLINE(R)
099			_a33598853
245			_aLongitudinal uncoupling of the heart and arteries with aging in a community-dwelling population.
251			_aGeroScience. 2021 Feb 18
252			_aGeroscience. 2021 Feb 18
253			_aGeroScience
260			_c2021
260			_fFY2021
265			_saheadofprint
266			_d2021-03-10
520			_aAlthough mechanical energy transfer between the heart and arterial system, referred to as arterial-ventricular (AV) coupling, is an important determinant of cardiovascular performance, how AV coupling changes over time within and among individuals as they age has not been fully explored. We studied 129 participants (baseline age 21-96) of the Baltimore Longitudinal Study of Aging, free of clinical CVD. Participants underwent repeated multigated cardiac blood pool scans to estimate left ventricular (LV) volumes (SV, EDV, and ESV). Total systemic vascular resistance (TSVR), total arterial compliance (TAC), effective arterial elastance (Ea), and end-systolic LV elastance (Elv) were calculated using LV volumes and brachial BP measurements; calculated Ea/Elv was the measure of AV coupling. Linear mixed-effects models were used to estimate person-specific rates of change (Change) for each variable. The rate at which Ea increased over time was faster than the rate at which Elv increased, resulting in AV uncoupling (increased Ea/Elv) over time that was significantly greater in women than in men. Loss of arterial compliance was the main determinant of (Ea/Elv)Change, which was negatively associated with changes in SV and EDV but positively with changes in ESV. Progressive AV uncoupling occurred with aging and was more pronounced in women than men. While Ea change did not differ by sex, Elv increased at a slower rate in women than in men. AV uncoupling was inversely associated with EDV and SV rates of change and a directly associated with an increase in ESV rate of change. Additional studies are needed to explore the functional consequences of AV uncoupling in healthy individuals with respect to the emergence of age-associated clinical cardiovascular diseases, such as heart failure with preserved ejection fraction.
546			_aEnglish
650			_aIN PROCESS -- NOT YET INDEXED
651			_aMedStar Heart & Vascular Institute
657			_aJournal Article
700			_aNajjar, Samer S
790			_aAlGhatrif M, Becker LC, Chantler PD, Ferrucci L, Gerstenblith G, Lakatta EG, Morrell CH, Najjar SS
856			_uhttps://dx.doi.org/10.1007/s11357-020-00321-x _zhttps://dx.doi.org/10.1007/s11357-020-00321-x
942			_cART _dArticle
999			_c6220 _d6220