000			03163nam a22003737a 4500
008			220221s20222022 xxu||||| |||| 00| 0 eng d
024			_a00001665-900000000-91909 [pii]
024			_a10.1097/SCS.0000000000008464 [doi]
040			_aOvid MEDLINE(R)
099			_a35013073
245			_aCraniofacial Dysmorphology in Infants With Non-Syndromic Unilateral Coronal Craniosynostosis.
251			_aJournal of Craniofacial Surgery. 2022 Jan 10
252			_aJ Craniofac Surg. 2022 Jan 10
253			_aThe Journal of craniofacial surgery
260			_c2022
260			_fFY2022
260			_p2022 Jan 10
265			_saheadofprint
266			_d2022-02-21
501			_aAvailable online from MWHC library: 2001 - present, Available in print through MWHC library:1999-2007
520			_aBACKGROUND: Unilateral coronal craniosynostosis (UCS) is a congenital disorder resulting from the premature suture fusion, leading to complex primary and compensatory morphologic changes in the shape of not only the calvarium and but also into the skull base. This deformity typically requires surgery to correct the shape of the skull and prevent neurologic sequelae, including increased intracranial pressure, sensory deficits, and cognitive impairment.
520			_aCONCLUSIONS: The described technique illustrates the impact of premature coronal suture fusion on the development of the entire skull and proposes how bone dysmorphology contributes to the patients' neurologic sequelae. By bridging novel basic science methodologies with clinical research, the present study quantitatively describes craniofacial development and bone dysmorphogenesis. Copyright (c) 2022 by Mutaz B. Habal, MD.
520			_aMETHODS: The present multicenter study sought to reverse-engineer the bone dysmorphogenesis seen in non-syndromic UCS using a geometric morphometric approach. Computed tomography scans for 26 non-syndromic UCS patients were converted to three-dimensional mesh models. Two hundred thirty-six unique anatomical landmarks and semi-landmarked curves were then plotted on each model, creating wireframe representations of the patients' skulls.
520			_aRESULTS: Generalized Procrustes superimposition, Principal Component Analysis, and heatmaps identified significant superior displacement of the ipsilateral orbit ("harlequin" eye deformity), anterior displacement of the ear ipsilateral to the fused coronal suture, acute deviation of midline skull base structures ipsilateral to the fused coronal suture and flattening of the parietal bone and associated failure to expand superiorly.
546			_aEnglish
650			_aIN PROCESS -- NOT YET INDEXED
656			_aMedStar Georgetown University Hospital/MedStar Washington Hospital Center
656			_aPlastic Surgery Residency
657			_aJournal Article
700			_aMargulies, Ilana
790			_aBellaire CP, Delman BN, Devarajan A, Goel P, Jacob L, Liu H, Mandelbaum M, Margulies IG, Napoli JG, Rutland JW, Sayegh F, Taub PJ, Urata MM
856			_uhttps://dx.doi.org/10.1097/SCS.0000000000008464 _zhttps://dx.doi.org/10.1097/SCS.0000000000008464
942			_cART _dArticle
999			_c833 _d833